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Effects of ephedrine on human nasal ciliary beat frequency.

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机构： [1]Beijing Institute of Otorhinolaryngology, Beijing Tongren Hospital, Capital University of Medical Sciences, Beijing , PR China [2]Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital University of Medical Sciences, Beijing , PR China

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关键词： Ephedrine Ciliary beat frequency Nasal epithelial cells Microscopy

摘要：

The purpose of this study was to investigate the effects of ephedrine, an alpha,beta-adrenoceptor agonist, on the regulation of human nasal ciliary beat frequency (CBF). Changes in (cultured) human nasal CBF in response to 0.25, 0.5, 1.0 and 2.0% ephedrine were quantified by using high-speed (240 frames per second) digital microscopy combined with a beat-by-beat CBF analysis. At approximately 25 degrees C, we found that ephedrine induces an instant and moderate increase in human nasal CBF followed by an inhibitory response. With concentrations ranging from 0.25 to 2.0%, while the increment is independent of ephedrine concentration, the inhibitory effect is dependent on the concentration of ephedrine. Based on these results we propose that the clinically used concentration of ephedrine, 0.5%, has maximum stimulatory effect without obvious inhibitory effect on (cultured) human nasal CBF.

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出版当年[2007]版：

大类 | 4 区医学

最新[2025]版：

大类 | 4 区医学

小类 | 4 区耳鼻喉科学

第一作者：

第一作者机构： [1]Beijing Institute of Otorhinolaryngology, Beijing Tongren Hospital, Capital University of Medical Sciences, Beijing , PR China [2]Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital University of Medical Sciences, Beijing , PR China

通讯作者：

通讯机构： [1]Beijing Institute of Otorhinolaryngology, Beijing Tongren Hospital, Capital University of Medical Sciences, Beijing , PR China [2]Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital University of Medical Sciences, Beijing , PR China [*1]Department of Otolaryngology, Head and Neck Surgery Beijing Tongren Hospital 1, Dong Jiao Min Xiang Street, DongCheng District, Beijing 100730 (PR China)

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