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Evaluation of the Diagnostic Performance of Swept-Source Anterior Segment Optical Coherence Tomography in Primary Angle Closure Disease

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收录情况： ◇ SCIE

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机构： [1]the Department of Ophthalmology,University of California, San Francisco, San Francisco, Caliornia, USA Department of Ophthalmology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China. [2]State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China. [3]the Department of Ophthalmology,University of California, San Francisco, San Francisco, Caliornia, USA. [4]Center for Preventive Ophthalmology and Biostatistics, Department of Ophthalmology, University of Pennsylvania, Philadelphia, Pennsylvania, USA. [5]Singapore Eye Research Institute, Singapore National Eye Centre, Singapore. [6]State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, East Melbourne, Victoria, Australia. [7]Singapore Eye Research Institute, Singapore National Eye Centre, Singapore Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. [8]Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China. [9]State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China [10]Department of Ophthalmology,University of California, San Francisco, San Francisco, Caliornia, USA,Department of Ophthalmology,University of California, San Francisco, San Francisco, Caliornia, USA Ophthalmology Section, Surgical Service, San Francisco Veterans Affairs Medical Center, San Francisco,

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center dot PURPOSE: To evaluate the diagnostic performance of swept-source anterior segment optical coherence tomography (SS-OCT) in differentiating eyes with primary angle closure disease (PACD) from eyes of control subjects, as well as eyes with PAC and PAC glaucoma (PACG) from eyes with PAC suspect (PACS) disease. center dot DESIGN: Multicenter cross-sectional study. center dot METHODS: Chinese patients were classified into control, PACS, and PAC/PACG groups. The area under the receiving operating characteristic curve (AUC) from logistic regression models was used to evaluate discriminating ability. Sensitivity and specificity were calculated, and performance of the models was validated using an independent dataset. center dot RESULTS: A total of 2928 SS-OCT images from 366 eyes of 260 patients were recruited to develop diagnostic models. The validation dataset included 1176 SS-OCT images from 147 eyes of 143 patients. For distinguishing PACD from control eyes, average anterior chamber depth had the highest AUC (0.94). With a cutoff of 2.2 mm for average anterior chamber depth, the sensitivity and specificity were 90.2% and 85.2% in the training set. For distinguishing PAC/PACG from PACS, a multivariate model had an AUC of 0.83, with sensitivity and specificity of 82.0% and 62.8% in the training set. The validation set confirmed the findings. center dot CONCLUSIONS: SS-OCT of the anterior segment showed excellent diagnostic performance distinguishing PACD from normal eyes and moderate diagnostic ability distinguishing eyes with PAC/PACG from eyes with PACS. ACD alone may provide a simple and effective way to diagnose PACD from control subjects. As ACD can be obtained using other more available modalities, this has implications for the early diagnosis of PACD. (Am J Ophthalmol 2021;233: 68-77. Published by Elsevier Inc.)

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出版当年[2021]版：

大类 | 2 区

医学

小类 | 1 区眼科学

最新[2023]版：

大类 | 1 区

医学

小类 | 1 区眼科学

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出版当年[2020]版：

Q1 OPHTHALMOLOGY

最新[2023]版：

Q1 OPHTHALMOLOGY

影响因子： 4.1 最新[2023版] 4.4 最新五年平均 5.258 出版当年[2020版] 5.729 出版当年五年平均 4.013 出版前一年[2019版] 5.488 出版后一年[2021版]

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第一作者机构： [1]the Department of Ophthalmology,University of California, San Francisco, San Francisco, Caliornia, USA Department of Ophthalmology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.

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