The progression, metastasis, and prognosis of cervical cancer (CC) is influenced by the tumor immune microenvironment. Studies proved that long non-coding RNAs (lncRNAs) to engage in cervical cancer development, especially immune-related lncRNAs, have emerged crucial in the tumor immune process. This study was set out to identify an immune-related lncRNA signature. In total, 13,838 lncRNA expression profiles and 328 immune genes were acquired from the clnical data of 306 CC tissues and 3 non-CC tissues. From the 433 identified immune-related lncRNAs, 4 candidate immune-related lncRNAs (SOX21-AS1, AC005332.4, NCK1-DT, LINC01871) were considered independent indicators of cervical cancer prognosis through the univariate and multivariate Cox regression analysis, and they were used to construct a prognostic and survival lncRNA signature model followed by the bootstrap method for further verification. Kaplan-Meier curves illustrated that cervical cancer patients could be divided into high-risk and low-risk groups with significant differences (P = 2.052e - 05), and the discrepancy of immune profiles between these two risk groups was illustrated by principal components analysis. Taken together, the novel survival predictive model created by the four immune-related lncRNAs showed promising clinical prediction value in cervical cancer.
基金：
National Natural Science
Foundation of China (No. 81903006) and Changning District Science
and Technology Commission (No.CNKW2018Y06).
第一作者机构：[1]Shanghai Jiao Tong Univ, Tongren Hosp, Hongqiao Int Inst Med, Sch Med, 1111 XianXia Rd, Shanghai 200336, Peoples R China[2]Shanghai Jiao Tong Univ, Tongren Hosp, Obstet & Gynecol Dept, Sch Med, 1111 XianXia Rd, Shanghai 200336, Peoples R China
通讯作者：
通讯机构：[1]Shanghai Jiao Tong Univ, Tongren Hosp, Hongqiao Int Inst Med, Sch Med, 1111 XianXia Rd, Shanghai 200336, Peoples R China[2]Shanghai Jiao Tong Univ, Tongren Hosp, Obstet & Gynecol Dept, Sch Med, 1111 XianXia Rd, Shanghai 200336, Peoples R China
推荐引用方式(GB/T 7714)：
Xu Min,Zhang Runjie,Qiu Jin.A four immune-related long noncoding RNAs signature as predictors for cervical cancer[J].HUMAN CELL.2022,35(1):348-359.doi:10.1007/s13577-021-00654-5.
APA：
Xu, Min,Zhang, Runjie&Qiu, Jin.(2022).A four immune-related long noncoding RNAs signature as predictors for cervical cancer.HUMAN CELL,35,(1)
MLA：
Xu, Min,et al."A four immune-related long noncoding RNAs signature as predictors for cervical cancer".HUMAN CELL 35..1(2022):348-359
