Michler's ethylketone (MEK, 4,4 '-bis(diethylamino)benzophenone), commonly-known as an intermediate in the synthesis of dyes and pigments, was successfully screened and optimized as a novel matrix for the enhancement of lipid in situ detection and imaging in tissues by MALDI-MSI. The results show several properties of MEK as a powerful MALDI matrix, including strong UV absorption, mu m-sized crystals and uniform matrix-coating, super high vacuum chemical stability, low matrix-related ion interference, super soft ionization, and high lipid ionization efficiency.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31770384, 21605164]; Huayi Technology Innovation Center for Research Resources [HTIC P01 RR2017001A]; Youth Elite Project of National Ethnic Affairs Commission of P. R. China [10301-0190040110]; Double World-First Class Development Program of MUC [Yldxxk201819]
第一作者机构：[1]Minzu Univ China, State Ethn Affairs Commiss, Key Lab Mass Spectrometry Imaging & Metabol, Beijing 100081, Peoples R China[2]Minzu Univ China, Coll Life & Environm Sci, Ctr Imaging & Syst Biol, Beijing 100081, Peoples R China
共同第一作者：
通讯作者：
通讯机构：[1]Minzu Univ China, State Ethn Affairs Commiss, Key Lab Mass Spectrometry Imaging & Metabol, Beijing 100081, Peoples R China[2]Minzu Univ China, Coll Life & Environm Sci, Ctr Imaging & Syst Biol, Beijing 100081, Peoples R China
推荐引用方式(GB/T 7714)：
Shi Yiyang,Hu Hao,Hao Qichen,et al.Michler's ethylketone as a novel negative-ion matrix for the enhancement of lipid MALDI tissue imaging[J].CHEMICAL COMMUNICATIONS.2022,58(5):633-636.doi:10.1039/d1cc05718a.
APA：
Shi, Yiyang,Hu, Hao,Hao, Qichen,Wu, Ran,Wang, Lei...&Wang, Xiaodong.(2022).Michler's ethylketone as a novel negative-ion matrix for the enhancement of lipid MALDI tissue imaging.CHEMICAL COMMUNICATIONS,58,(5)
MLA：
Shi, Yiyang,et al."Michler's ethylketone as a novel negative-ion matrix for the enhancement of lipid MALDI tissue imaging".CHEMICAL COMMUNICATIONS 58..5(2022):633-636
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