Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life Years for 29 Cancer Groups From 2010 to 2019 A Systematic Analysis for the Global Burden of Disease Study 2019
机构：[1]Department of Epidemiology and Health Statistics,Southeast University, Nanjing, China[2]School of Public Health, University of Hong Kong, Hong Kong, China[3]Department of Pharmacy Administration and Clinical Pharmacy, Xian Jiaotong University, Xian,China[4]Department of Microbiology, Nankai University, Tianjin, China[5]Jockey Club School of Public Health and Primary Care, Chinese University of Hong Kong, Hong Kong, China[6]Department of Occupational Safety and Health, China Medical University,Taichung, Taiwan[7]Department of Medical Oncology, Peking Union Medical College, Beijing,China[8]Department of Epidemiology and Biostatistics, Wuhan University, Wuhan, China[9]Bone Marrow Transplantation Center, Zhejiang University, Hangzhou, China[10]School of Medicine, Tsinghua University, Beijing, China[11]Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Beijing, China研究所眼科研究所首都医科大学附属北京同仁医院首都医科大学附属同仁医院
IMPORTANCE The Global Burden of Diseases, Injuries, and Risk Factors Study 2019 (GBD 2019) provided systematic estimates of incidence, morbidity, and mortality to inform local and international efforts toward reducing cancer burden. OBJECTIVE To estimate cancer burden and trends globally for 204 countries and territories and by Sociodemographic Index (SDI) quintiles from 2010 to 2019. EVIDENCE REVIEW The GBD 2019 estimation methods were used to describe cancer incidence, mortality, years lived with disability, years of life lost, and disability-adjusted life years (DALYs) in 2019 and over the past decade. Estimates are also provided by quintiles of the SDI, a composite measure of educational attainment, income per capita, and total fertility rate for those younger than 25 years. Estimates include 95% uncertainty intervals (UIs). FINDINGS In 2019, there were an estimated 23.6 million (95% UI, 22.2-24.9 million) new cancer cases (17.2 million when excluding nonmelanoma skin cancer) and 10.0 million (95% UI, 9.36-10.6 million) cancer deaths globally, with an estimated 250 million (235-264 million) DALYs due to cancer. Since 2010, these represented a 26.3%(95% UI, 20.3%-32.3%) increase in new cases, a 20.9%(95% UI, 14.2%-27.6%) increase in deaths, and a 16.0% (95% UI, 9.3%-22.8%) increase in DALYs. Among 22 groups of diseases and injuries in the GBD 2019 study, cancer was second only to cardiovascular diseases for the number of deaths, years of life lost, and DALYs globally in 2019. Cancer burden differed across SDI quintiles. The proportion of years lived with disability that contributed to DALYs increased with SDI, ranging from 1.4%(1.1%-1.8%) in the low SDI quintile to 5.7%(4.2%-7.1%) in the high SDI quintile. While the high SDI quintile had the highest number of new cases in 2019, the middle SDI quintile had the highest number of cancer deaths and YDALYs. From 2010 to 2019, the largest percentage increase in the numbers of cases and deaths occurred in the low and low-middle SDI quintiles. CONCLUSIONS AND RELEVANCE The results of this systematic analysis suggest that the global burden of cancer is substantial and growing, with burden differing by SDI. These results provide comprehensive and comparable estimates that can potentially inform efforts toward equitable cancer control around the world.
基金：
Bill & Melinda Gates Foundation; American Lebanese Syrian Associated Charities; Department of Health Policy and Management of Kuwait University; International Centre for Casemix and Clinical Coding, National University of Malaysia; Alexander von Humboldt Foundation through the Alexander von Humboldt Professor award - German Federal Ministry of Education and Research; National Institutes of Health/National Cancer Institute; European Research Council ERC Starting Grant [848325]; Portuguese national funds through Fundacao para a Ciencia e Tecnologia, IP under the Norma Transitoria grant [SFRH/BHD/110001/2015, DL57/2016/CP1334/CT0006]; Novo Nordisk Foundation [NNF16OC0021856]; National Institute of Health Research Doctoral Research Fellowship; National Health and Medical Research Council Australia; Romanian National Authority for Scientific Research and Innovation, CNDS-UEFISCDI, project [PN-III-P4-ID-PCCF-2016-0084]; Higher Education Improvement Coordination of the Brazilian Ministry of Education; National Heart Foundation of Australia Fellowship; National Health and Medical Research Council Emerging Leadership Fellowship; Ministry of Education Science and Technological Development of the Republic of Serbia [OI 175014]; NHS Research Scotland Senior Clinical Fellowship [SCAF/15/02]; Medical Research Council [MC_UU_00022/2]; Scottish Government Chief Scientist Office [SPHSU17]; Jatiya Kabi Kazi Nazrul Islam University, Bangladesh; Research Management Centre, Xiamen University Malaysia [XMUMRF/2020-C6/ITCM/0004]; Panama's Secretaria Nacional de Ciencia, Tecnologia e Innovacion; Fundacao para a Ciencia e Tecnologia under the Scientific Employment Stimulus-Institutional Call [CEECINST/00049/2018]; National Institute for Health Research Biomedical Research Center at Guy's and St Thomas' National Health Service Foundation Trust; King's College London; NIGEB; SIAN Institute, Association for Biodiversity Conservation Research; government of the Russian Federation; Egyptian Fulbright Mission Program; Health Data Research UK; Kasturba Medical College, Mangalore, Manipal Academy of Higher Education; Manipal Academy of Higher Education; Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior Brasil [001]; CNPq [302028/2018-8]; Cancer Prevention and Research Institute of Texas grant [RP210042]
第一作者机构：[1]Department of Epidemiology and Health Statistics,Southeast University, Nanjing, China
通讯作者：
通讯机构：[*1]Institute for Health Metrics and Evaluation, Population Health Building/Hans Rosling Center, University of Washington, Box #351615, 3980 15th Ave NE, Seattle, WA 98195
推荐引用方式(GB/T 7714)：
Tauseef Ahmad,Ester Cerin,Khezar Hayat,et al.Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life Years for 29 Cancer Groups From 2010 to 2019 A Systematic Analysis for the Global Burden of Disease Study 2019[J].JAMA ONCOLOGY.2022,8(3):420-444.doi:10.1001/jamaoncol.2021.6987.
APA：
Tauseef Ahmad,Ester Cerin,Khezar Hayat,Kamal Hezam,Junjie Huang...&Jonathan M.Kocarnik.(2022).Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life Years for 29 Cancer Groups From 2010 to 2019 A Systematic Analysis for the Global Burden of Disease Study 2019.JAMA ONCOLOGY,8,(3)
MLA：
Tauseef Ahmad,et al."Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life Years for 29 Cancer Groups From 2010 to 2019 A Systematic Analysis for the Global Burden of Disease Study 2019".JAMA ONCOLOGY 8..3(2022):420-444
医学