机构：[1]Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing 100005, China.研究所眼科研究所首都医科大学附属北京同仁医院首都医科大学附属同仁医院[2]School of Medicine, University of Central Lancashire, Preston, UK.[3]Quinze‑Vingts National Ophthalmology Hospital, IHU FOReSIGHT, Paris and Versailles Saint-Quentin-en-Yvelines University, Versailles, France.[4]Institut de la Vision, IHU FOReSIGHT, Sorbonne Université, INSERM, CNRS, 17 rue Moreau, 75012 Paris, France.
Increased prevalence of depression has been found in patients with meibomian gland dysfunction (MGD); however, specific conditions of patients suffered from MGD and depression remains unclear. Our aim was to investigate the prevalence of depression in patients with MGD and analyze the risk factors of depression in MGD patients. In this multi-center cross-sectional study, we enrolled 830 MGD patients and 114 normal controls. Demographic information was collected by designed questionnaires about lifestyle habits, systemic and ocular medical history. Ophthalmic examinations were performed in a formal order. Depression symptoms were evaluated with a questionnaire survey using a modified self-rating depression scale (M-SDS). The correlations between the M-SDS score and demographic and clinical information were analyzed. The prevalence of hyperlipidemia and obstructive sleep apnea-hypopnea syndrome (OSAHS) was higher in the MGD group. There were 78 cases (9.4%) with depressive symptoms in the MGD group whereas there were 4 cases (3.5%) in controls. Similarly, M-SDS was higher in the MGD group. The characteristics of depression in the MGD group included: crying spells, sleep disturbance and depressed appetite. Some systemic diseases (OSAHS, allergy, skin disease) and the use of contact lenses was correlated with an increased risk of depressive symptoms in MGD patients.
基金：
National Natural Science Foundation of China (NSFC) [81970765]
第一作者机构：[1]Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing 100005, China.
通讯作者：
推荐引用方式(GB/T 7714)：
Wei Zhenyu,Liang Junqi,Cao Kai,et al.A multi-center study evaluating the correlation between meibomian gland dysfunction and depressive symptoms[J].SCIENTIFIC REPORTS.2022,12(1):doi:10.1038/s41598-021-04167-x.
APA：
Wei, Zhenyu,Liang, Junqi,Cao, Kai,Wang, Leying,Baudouin, Christophe...&Liang, Qingfeng.(2022).A multi-center study evaluating the correlation between meibomian gland dysfunction and depressive symptoms.SCIENTIFIC REPORTS,12,(1)
MLA：
Wei, Zhenyu,et al."A multi-center study evaluating the correlation between meibomian gland dysfunction and depressive symptoms".SCIENTIFIC REPORTS 12..1(2022)
