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Consensus Recommendation for Mouse Models of Ocular Hypertension to Study Aqueous Humor Outflow and Its Mechanisms

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机构: [1]Univ Wisconsin, Dept Ophthalmol & Visual Sci, Madison, WI USA [2]Jackson Lab, 600 Main St, Bar Harbor, ME 04609 USA [3]Univ Oklahoma, Hlth Sci Ctr, Oklahoma City, OK USA [4]Imperial Coll London, Dept Bioengn, London, England [5]Univ North Texas, Dept Pharmacol & Neurosci, Hlth Sci Ctr, Ft Worth, TX USA [6]Univ North Texas, North Texas Eye Res Inst, Hlth Sci Ctr, Ft Worth, TX USA [7]Univ Iowa, Dept Ophthalmol & Visual Sci, Iowa City, IA USA [8]Univ Iowa, Inst Vis Res, Iowa City, IA USA [9]Vet Affairs Med Ctr, Ctr Prevent & Treatment Visual Loss, Iowa City, IA USA [10]Oregon Hlth & Sci Univ, Ophthalmol & Biochem & Mol Biol, Casey Eye Inst, Portland, OR 97201 USA [11]Univ Iowa, Dept Mol Physiol & Biophys, Iowa City, IA USA [12]Univ Miami, Bascom Palmer Eye Inst, Miami, FL USA [13]Univ N Carolina, Chapel Hill, NC USA [14]Brightfocus Fdn, Clarksburg, MD USA [15]SUNY Downstate Hlth Sci Univ, Brooklyn, NY USA [16]Duke Univ, Duke Eye Ctr, Dept Ophthalmol, Durham, NC USA [17]Univ Pittsburgh, Dept Ophthalmol, Pittsburgh, PA USA [18]Univ Wisconsin, Dept Pathol & Lab Med, Madison, WI USA [19]Univ Regensburg, Inst Human Anat & Embryol, Regensburg, Germany [20]SUNY Upstate Med Univ, Dept Ophthalmol & Visual Sci, Syracuse, NY 13210 USA [21]Boston Univ, Sch Med, Dept Ophthalmol, Boston, MA 02118 USA [22]Univ Houston Victoria, Victoria, TX USA [23]Trinity Coll Dublin, Smurfit Inst Genet, Dublin, Ireland [24]Columbia Univ, Dept Ophthalmol, New York, NY 10027 USA [25]Oregon Hlth & Sci Univ, Casey Eye Inst, Portland, OR 97201 USA [26]Oregon Hlth & Sci Univ, Dept Ophthalmol, Portland, OR USA [27]Oregon Hlth & Sci Univ, Dept Integrat Biosci, Portland, OR 97201 USA [28]Trinity Coll Dublin, Smurfit Inst Genet, Ocular Genet Unit, Dublin, Ireland [29]Univ Utah, Sch Med, Dept Ophthalmol, Salt Lake City, UT USA [30]Univ Calif Davis, Dept Surg & Radiol Sci, Davis, CA 95616 USA [31]Georgia Inst Technol, Dept Chem & Biochem, Atlanta, GA 30332 USA [32]Duke Univ, Dept Ophthalmol, Durham, NC USA [33]Duke Univ, Dept Pathol, Durham, NC 27706 USA [34]Augusta Univ, James & Jean Culver Vis Discovery Inst, Dept Cellular Biol & Anat, Augusta, GA USA [35]Duke Hlth, Duke Eye Ctr, Durham, NC USA [36]Univ Utah, Dept Neurobiol, Salt Lake City, UT USA [37]Indiana Univ Sch Med, Dept Ophthalmol, Indianapolis, IN 46202 USA [38]Univ Wisconsin, Dept Surg Sci, Madison, WI USA [39]Univ Houston, Coll Optometry, Houston, TX USA [40]Icahn Sch Med Mt Sinai, Dept Ophthalmol, New York, NY USA [41]Regeneron Pharmaceut, Ophthalmol Res, Tarreytown, NY USA [42]Duke Univ, Dept Ophthalmol, Sch Med, Durham, NC USA [43]Univ Calif Irvine, Dept Neurobiol, Irvine, CA USA [44]Case Western Reserve Univ, Sch Med, Cleveland, OH 44106 USA [45]Mayo Clin, Dept Ophthalmol, Rochester, MN 55902 USA [46]Washington State Univ, Floyd Elson Coll Med, Spokane, WA USA [47]Western Glaucoma Fdn, Sisters, OR USA [48]Santen Inc, Emeryville, CA USA [49]NYU, NYU Langone Hlth, NYU Grossman Sch Med, Dept Ophthalmol, New York, NY USA [50]NYU, NYU Langone Hlth, NYU Grossman Sch Med, Dept Physiol & Neurosci, New York, NY USA [51]NYU, Dept Biomed Engn, Tandon Sch Engn, Brooklyn, NY USA [52]NYU, Dept Elect, Tandon Sch Engn, Brooklyn, NY USA [53]NYU, Coll Arts & Sci, Ctr Neural Sci, New York, NY USA [54]Univ Iowa, Dept Pediat, Carver Coll Med, Iowa City, IA 52242 USA [55]Univ Iowa, Dept Ophthalmol & Visual Sci, Carver Coll Med, Iowa City, IA USA [56]Stanford Univ, Vet Affairs Palo Alto Hlth Care Syst, Palo Alto, CA 94304 USA [57]Univ Nebraska Med Ctr, Dept Ophthalmol & Visual Sci, Omaha, NE USA [58]Ohio State Univ, Dept Ophthalmol & Vis Sci, Columbus, OH 43210 USA [59]Glauconix Biosci, Albany, NY USA [60]Northwestern Univ, Cell & Dev Biol Dept, Chicago, IL 60611 USA [61]Oregon Hlth & Sci Univ, Dept Ophthalmol, Casey Eye Inst, Portland, OR 97201 USA [62]Ulster Univ, Biomed Sci Res Inst, Genom Med, Coleraine, Londonderry, North Ireland [63]Capital Med Univ, Beijing Tongren Hosp, Beijing Tongren Eye Ctr, Beijing Inst Ophthalmol, Beijing, Peoples R China [64]Northwestern Univ, Dept Biomed Engn, Evanston, IL 60208 USA [65]Univ Regensburg, Regensburg, Germany [66]Univ North Texas, North Texas Eye Res Inst, Dept Pharmacol & Neurosci, Hlth Sci Ctr, Ft Worth, TX 76107 USA [67]Georgia Inst Technol, Wallace H Coulter Dept Biomed Engn, Atlanta, GA 30332 USA [68]Emory Univ, Sch Med, Atlanta, GA 30322 USA [69]Duke Univ, Duke Ophthalmol, Durham, NC 27708 USA
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关键词: mouse model conventional outflow glaucoma intraocular pressure ocular hypertension outflow facility

摘要:
Due to their similarities in anatomy, physiology, and pharmacology to humans, mice are a valuable model system to study the generation and mechanisms modulating conventional outflow resistance and thus intraocular pressure. In addition, mouse models are critical for understanding the complex nature of conventional outflow homeostasis and dysfunction that results in ocular hypertension. In this review, we describe a set of minimum acceptable standards for developing, characterizing, and utilizing mouse models of open-angle ocular hypertension. We expect that this set of standard practices will increase scientific rigor when using mouse models and will better enable researchers to replicate and build upon previous findings.

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出版当年[2021]版:
大类 | 2 区 医学
小类 | 2 区 眼科学
最新[2023]版:
大类 | 2 区 医学
小类 | 2 区 眼科学
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出版当年[2020]版:
Q1 OPHTHALMOLOGY
最新[2023]版:
Q1 OPHTHALMOLOGY

影响因子: 最新[2023版] 最新五年平均 出版当年[2020版] 出版当年五年平均 出版前一年[2019版] 出版后一年[2021版]

第一作者:
第一作者机构: [1]Univ Wisconsin, Dept Ophthalmol & Visual Sci, Madison, WI USA
通讯作者:
通讯机构: [45]Mayo Clin, Dept Ophthalmol, Rochester, MN 55902 USA [64]Northwestern Univ, Dept Biomed Engn, Evanston, IL 60208 USA [67]Georgia Inst Technol, Wallace H Coulter Dept Biomed Engn, Atlanta, GA 30332 USA [68]Emory Univ, Sch Med, Atlanta, GA 30322 USA
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