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Plexus-specific retinal capillary avascular area in exudative age-related macular degeneration with projection-resolved OCT angiography

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机构: [1]Ophthalmology, Beijing Tongren Eye Center, Beijing, China [2]Ophthalmology, Casey Eye Institute, Oregon Health & Science University, Portland, Oregon, USA
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Objective To detect the plexus-specific retinal capillary avascular area in exudative age-related macular degeneration (EAMD) with projection-resolved optical coherence tomography angiography (PR-OCTA). Methods and analysis In this prospective cross-sectional single centre study, eyes with treatment-naive EAMD underwent macular 3x3 mm OCTA with AngioVue system. OCTA scans were analysed and processed including three-dimensional projection artefact removal, retinal layer semi-automated segmentation and en face angiogram generation. Automated quantification of extrafoveal (excluding the central 1 mm circle) avascular area (EAA) were calculated on projection-resolved superficial vascular complex (SVC), intermediate capillary plexus (ICP) and deep capillary plexus (DCP), respectively. Results Nineteen eyes with EAMD and 19 age-matched healthy control eyes were included. There was no significant difference between the EAMD and control eyes in terms of age, sex, axial length and mean ocular perfusion pressure (all p>0.05). Compared with control eyes, EAMD eyes had significantly larger EAA in SVC (median 0.125 vs 0.059 mm(2), p=0.006), ICP (0.016 vs 0.000 mm(2), p=0.004) and DCP (0.033 vs 0.000 mm2, p<0.001). Conclusion PR-OCTA showed that EAMD is associated with focal avascular area in all the three retinal vascular plexuses.

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出版当年[2021]版:
大类 | 2 区 医学
小类 | 1 区 眼科学
最新[2023]版:
大类 | 2 区 医学
小类 | 2 区 眼科学
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出版当年[2020]版:
Q1 OPHTHALMOLOGY
最新[2023]版:
Q1 OPHTHALMOLOGY

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第一作者机构: [1]Ophthalmology, Beijing Tongren Eye Center, Beijing, China
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通讯机构: [2]Ophthalmology, Casey Eye Institute, Oregon Health & Science University, Portland, Oregon, USA [*1]Casey Eye Institute, Oregon Health & Science University, Portland, OR 97239, USA
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