机构:[1]Ophthalmology, Beijing Tongren Eye Center, Beijing, China首都医科大学附属北京同仁医院首都医科大学附属同仁医院[2]Ophthalmology, Casey Eye Institute, Oregon Health & Science University, Portland, Oregon, USA
Objective To detect the plexus-specific retinal capillary avascular area in exudative age-related macular degeneration (EAMD) with projection-resolved optical coherence tomography angiography (PR-OCTA). Methods and analysis In this prospective cross-sectional single centre study, eyes with treatment-naive EAMD underwent macular 3x3 mm OCTA with AngioVue system. OCTA scans were analysed and processed including three-dimensional projection artefact removal, retinal layer semi-automated segmentation and en face angiogram generation. Automated quantification of extrafoveal (excluding the central 1 mm circle) avascular area (EAA) were calculated on projection-resolved superficial vascular complex (SVC), intermediate capillary plexus (ICP) and deep capillary plexus (DCP), respectively. Results Nineteen eyes with EAMD and 19 age-matched healthy control eyes were included. There was no significant difference between the EAMD and control eyes in terms of age, sex, axial length and mean ocular perfusion pressure (all p>0.05). Compared with control eyes, EAMD eyes had significantly larger EAA in SVC (median 0.125 vs 0.059 mm(2), p=0.006), ICP (0.016 vs 0.000 mm(2), p=0.004) and DCP (0.033 vs 0.000 mm2, p<0.001). Conclusion PR-OCTA showed that EAMD is associated with focal avascular area in all the three retinal vascular plexuses.
基金:
National Institutes of Health [R01 EY024544, R01 EY027833, P30 EY010572]; Research to Prevent Blindness, New York
第一作者机构:[1]Ophthalmology, Beijing Tongren Eye Center, Beijing, China
通讯作者:
通讯机构:[2]Ophthalmology, Casey Eye Institute, Oregon Health & Science University, Portland, Oregon, USA[*1]Casey Eye Institute, Oregon Health & Science University, Portland, OR 97239, USA
推荐引用方式(GB/T 7714):
Gao Liqin,Wang Jie,You Qisheng,et al.Plexus-specific retinal capillary avascular area in exudative age-related macular degeneration with projection-resolved OCT angiography[J].BRITISH JOURNAL OF OPHTHALMOLOGY.2022,106(5):719-723.doi:10.1136/bjophthalmol-2020-317562.
APA:
Gao, Liqin,Wang, Jie,You, Qisheng,Guo, Yukun,Flaxel, Christina J....&Bailey, Steven T..(2022).Plexus-specific retinal capillary avascular area in exudative age-related macular degeneration with projection-resolved OCT angiography.BRITISH JOURNAL OF OPHTHALMOLOGY,106,(5)
MLA:
Gao, Liqin,et al."Plexus-specific retinal capillary avascular area in exudative age-related macular degeneration with projection-resolved OCT angiography".BRITISH JOURNAL OF OPHTHALMOLOGY 106..5(2022):719-723