Global death burden and attributable risk factors of peripheral artery disease by age, sex, SDI regions, and countries from 1990 to 2030: Results from the Global Burden of Disease study 2019
机构：[1]Department of Cardiology, Renmin Hospital, School of Basic Medical Sciences, Wuhan University, Wuhan, China[2]Institute of Model Animal of Wuhan University, Wuhan, China[3]Department of Cardiology, Zhongnan Hospital of Wuhan University, Wuhan, China[4]Department of Gastroenterology, Tongren Hospital of Wuhan University & Wuhan Third Hospital, Wuhan, China[5]Medical Science Research Center, Zhongnan Hospital of Wuhan University, Wuhan, China[6]Department of Cardiology, The Third Xiangya Hospital, Central South University, Changsha, China[7]Department of Cardiology, Huanggang Central Hospital, Huanggang, China[8]Huanggang Institute of Translational Medicine, Huanggang Central Hospital, Huanggang, China
Background and aims: Peripheral artery disease (PAD) is a prevalent cardiovascular disease. Understanding current and future disease burden of PAD and its attributable risk factors is critical for developing prevention measures targeting PAD and associated complications. Methods: We analyzed the death burden of PAD and the trends of six risk factors from 1990 to 2019 using the updated 2019 Global Burden of Disease study database, and projected the next decade death burden using a Bayesian age-period-cohort (BAPC) model. Results: The global age-standardized mortality rate (ASMR) of PAD has a modest downward trend from 1990 to 2019. Regionally, ASMRs in higher-sociodemographic index (SDI) areas remained more remarkable than in lower-SDI areas by 2019, while the rate of increase in death burden in the lower-SDI regions increased rapidly over time. ASMR in males was greater than in females. In the population aged older than 40 years, the sex difference in PAD-associated mortality decreased with age. High fasting plasma glucose (FPG) became the primary risk factor for PAD-related death. The contributions of risk factors to PAD-related death varied by age group. Kidney dysfunction was the primary contributor to PAD-related death in people aged 40-59 years, particularly in women. Conclusions: The global death burden of PAD has not substantially decreased over the three decades. There are large variations in the trend of PAD mortality and its attributable risk factors by SDI regions, sex, and age group. Targeted and effective strategies are needed for the management of PAD-related mortality in specific subgroups.
基金：
This work was supported by the National Key R&D Program of China [2016YFF0101504, 2020YFC2004702]; the National Science Foundation of China [81630011, 81970364, 81970070, 82070079, 81970011, 81770053, 81870171, 82000299]; the Hubei Science and Technology Support Project [2019BFC582, 2018BEC473]; the Medical flight plan of Wuhan University [TFJH2018006]; the Henan Charity Federation Hepatobiliary Fund [GDXZ2021008] and the Funded Project of Youth Teacher [2042020kf0051].
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2021]版：
大类|2 区医学
小类|2 区外周血管病3 区心脏和心血管系统
最新[2023]版：
大类|2 区医学
小类|2 区外周血管病3 区心脏和心血管系统
JCR分区：
出版当年[2020]版：
Q1PERIPHERAL VASCULAR DISEASEQ2CARDIAC & CARDIOVASCULAR SYSTEMS
第一作者机构：[1]Department of Cardiology, Renmin Hospital, School of Basic Medical Sciences, Wuhan University, Wuhan, China[2]Institute of Model Animal of Wuhan University, Wuhan, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Cardiology, Renmin Hospital, School of Basic Medical Sciences, Wuhan University, Wuhan, China[2]Institute of Model Animal of Wuhan University, Wuhan, China[5]Medical Science Research Center, Zhongnan Hospital of Wuhan University, Wuhan, China[8]Huanggang Institute of Translational Medicine, Huanggang Central Hospital, Huanggang, China[*1]School of Basic Medical Sciences, Wuhan University, 185 Donghu Rd, Wuhan 430071, China.[*2]Department of Cardiology, Renmin Hospital of Wuhan University, 99 Zhangzhidong Rd, Wuhan 430060, China.
推荐引用方式(GB/T 7714)：
Liu Weifang,Yang Chengzhang,Chen Ze,et al.Global death burden and attributable risk factors of peripheral artery disease by age, sex, SDI regions, and countries from 1990 to 2030: Results from the Global Burden of Disease study 2019[J].ATHEROSCLEROSIS.2022,347:17-27.doi:10.1016/j.atherosclerosis.2022.03.002.
APA：
Liu, Weifang,Yang, Chengzhang,Chen, Ze,Lei, Fang,Qin, Juan-Juan...&Li, Hongliang.(2022).Global death burden and attributable risk factors of peripheral artery disease by age, sex, SDI regions, and countries from 1990 to 2030: Results from the Global Burden of Disease study 2019.ATHEROSCLEROSIS,347,
MLA：
Liu, Weifang,et al."Global death burden and attributable risk factors of peripheral artery disease by age, sex, SDI regions, and countries from 1990 to 2030: Results from the Global Burden of Disease study 2019".ATHEROSCLEROSIS 347.(2022):17-27
医学