机构：[1]Department of Otorhinolaryngology Head and Neck Surgery, Central Hospital of Chaoyang, Liaoning, China[2]Department of Otorhinolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, China.临床科室耳鼻咽喉-头颈外科首都医科大学附属北京同仁医院首都医科大学附属同仁医院
Introduction: Hypopharyngeal carcinoma is one kind of high malignant tumour followed by poor prognosis in head and neck carcinomas. This study aimed to detect miR-29a-3p and Cdc42 in patients with hypopharyngeal carcinoma. Materials and Methods: The expression of miR-29a-3p and Cdc42 mRNA were detected, and the correlation between miR-29a-3p/Cdc42 and clinical stages was investigated. Results: The relative expression of miR-29a-3p in stage II, III and IV hypopharyngeal carcinoma tissues was significantly lower than that of stage I (P< 0.05). The relative expression of Cdc42 mRNA in stage II, III and IV tissues was significantly higher than that of stage I (P< 0.05). The expression of miR-29a-3p in hypopharyngeal carcinoma with lymph node metastasis was significantly lower than that without lymph node metastasis (P = 0.045). Conclusion: MiR-29a-3p and Cdc42 mRNA could be potential diagnostic biomarkers of hypopharyngeal carcinoma.
基金：
Liaoning Natural Science Foundation Program [2019-ZD-0901]; Beijing Natural Science Foundation Program and Scientific Research Key Program of Beijing Municipal Commission of Education [KZ201910025034]; Beijing Municipal Administration of Hospitals?; Ascent Plan [DFL20180202]
第一作者机构：[1]Department of Otorhinolaryngology Head and Neck Surgery, Central Hospital of Chaoyang, Liaoning, China
共同第一作者：
通讯作者：
通讯机构：[2]Department of Otorhinolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, China.[*1]Department of Otolaryngology Head Neck Surgery, Beijing Tongren Hospital, Capital Medical University, No.1, Dongjiaominxiang Street, Dongcheng District, Beijing, 100730, P.R. China.
推荐引用方式(GB/T 7714)：
Li Lianhe,Zou Liangyu,Yue Wenhui,et al.MicroRNA-29a-3p regulates chemosensitivity in hypopharyngeal carcinoma via targeting Cdc42[J].MALAYSIAN JOURNAL OF PATHOLOGY.2022,44(1):53-60.
APA：
Li, Lianhe,Zou, Liangyu,Yue, Wenhui,Liu, Chang,Wang, Hongmei...&Fang, Jugao.(2022).MicroRNA-29a-3p regulates chemosensitivity in hypopharyngeal carcinoma via targeting Cdc42.MALAYSIAN JOURNAL OF PATHOLOGY,44,(1)
MLA：
Li, Lianhe,et al."MicroRNA-29a-3p regulates chemosensitivity in hypopharyngeal carcinoma via targeting Cdc42".MALAYSIAN JOURNAL OF PATHOLOGY 44..1(2022):53-60
