机构：[1]Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu 610017, China四川大学华西医院[2]Save Sight Institute, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW2000, Australia[3]Canberra Health Services, Canberra, ACT 2605, Australia[4]Macular Disease Research Laboratory, Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu 610017, China四川大学华西医院[5]School of Optometry and Vision Science, University of New South Wales (UNSW), Sydney, NSW 2052, Australia[6]Department of Ocular Fundus Diseases, Beijing Tongren Eye Centre, Tongren Hospital, Capital Medical University, Beijing 100073, China首都医科大学附属北京同仁医院临床科室眼科眼底科[7]Beijing Retinal and Choroidal Vascular Study Group, Beijing 100073, China
The human retina, which is part of the central nervous system, has exceptionally high energy demands that requires an efficient metabolism of glucose, lipids, and amino acids. Dysregulation of retinal metabolism disrupts local energy supply and redox balance, contributing to the pathogenesis of diverse retinal diseases, including age-related macular degeneration, diabetic retinopathy, inherited retinal degenerations, and Macular Telangiectasia. A better understanding of the contribution of dysregulated metabolism to retinal diseases may provide better therapeutic targets than we currently have.
基金：
This research was funded by the Ophthalmic Research Institute of Australia (T.Z., M.G.),
the National Health and Medical Research Council (Investigator Grant GNT_1195021) (M.G.), the
Lowy Medical Research Institute (M.G., L.Z. and T.Z.).
第一作者机构：[1]Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu 610017, China[2]Save Sight Institute, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW2000, Australia
通讯作者：
通讯机构：[1]Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu 610017, China[4]Macular Disease Research Laboratory, Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu 610017, China
推荐引用方式(GB/T 7714)：
Chen Yingying,Coorey Nathan J.,Zhang Meixia,et al.Metabolism Dysregulation in Retinal Diseases and Related Therapies[J].ANTIOXIDANTS.2022,11(5):doi:10.3390/antiox11050942.
APA：
Chen, Yingying,Coorey, Nathan J.,Zhang, Meixia,Zeng, Shaoxue,Madigan, Michele C....&Zhang, Ting.(2022).Metabolism Dysregulation in Retinal Diseases and Related Therapies.ANTIOXIDANTS,11,(5)
MLA：
Chen, Yingying,et al."Metabolism Dysregulation in Retinal Diseases and Related Therapies".ANTIOXIDANTS 11..5(2022)
