Foveal structure changes in infants treated with anti-VEGF therapy or laser therapy guided by optical coherence tomography angiography for retinopathy of prematurity.
机构：[1]Peking University People's Hospital, Eye Diseases and Optometry Institute, Beijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroid Diseases, Department of Ophthalmology & Clinical Centre of Optometry, College of Optometry, Peking University Health Science Center, Beijing 100044, China.[2]Department of Ophthalmology, Children's Hospital of Soochow University, Suzhou 215003, Jiangsu Province, China.
To evaluate foveal vessel density (VD) and foveal thickness using optical coherence tomography angiography (OCTA) in retinopathy of prematurity (ROP) children treated with laser photocoagulation or anti-vascular endothelial growth factor (VEGF) injection. Additionally, we assessed the relationship between foveal microvascular anomalies and different therapies in ROP children.This was a single-center, retrospective study of patients with a diagnosis of type 1 ROP. Twenty-three eyes (14 patients) treated with anti-VEGF injection and twenty-nine eyes (17 patients) treated with laser coagulation were included in this study. The foveal VD, inner thickness and full thickness were measured at the central 0°, 2° to 8°, and 8° of the retina (centered on the fovea) using OCTA and cross-sectional OCT, respectively.Foveal VD, inner thickness and full thickness were significantly smaller within the central 8° of the retina in ROP children treated with anti-VEGF injection than in those treated with laser photocoagulation (P=0.013, 0.009, 0.036, respectively). The full thickness was also smaller in the anti-VEGF group than in the laser group at the central 0° of the retina (P=0.010). The grade of foveal hypoplasia is lower in the anti-VEGF group than in the laser group (P=0.045). Multivariable analysis did not find any risk factors associated with visual acuity in our study.In children with type 1 ROP, the better structural development of fovea in those who were treated with anti-VEGF injection compared with laser photocoagulation are identified. However, visual acuity outcomes are similar 70mo after the treatments.International Journal of Ophthalmology Press.
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外文
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出版当年[2021]版：
大类|4 区医学
小类|4 区眼科学
最新[2023]版：
大类|4 区医学
小类|4 区眼科学
第一作者：
第一作者机构：[1]Peking University People's Hospital, Eye Diseases and Optometry Institute, Beijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroid Diseases, Department of Ophthalmology & Clinical Centre of Optometry, College of Optometry, Peking University Health Science Center, Beijing 100044, China.
共同第一作者：
通讯作者：
通讯机构：[1]Peking University People's Hospital, Eye Diseases and Optometry Institute, Beijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroid Diseases, Department of Ophthalmology & Clinical Centre of Optometry, College of Optometry, Peking University Health Science Center, Beijing 100044, China.[*1]Department of Ophthalmology & Clinical Centre of Optometry, Peking University People’s Hospital, 11 Xizhimen South Street, Xicheng District, Beijing 100044, China
推荐引用方式(GB/T 7714)：
Deng Xun,Cheng Yong,Zhu Xue-Mei,et al.Foveal structure changes in infants treated with anti-VEGF therapy or laser therapy guided by optical coherence tomography angiography for retinopathy of prematurity.[J].International Journal of Ophthalmology.2022,15(1):106-112.doi:10.18240/ijo.2022.01.16.
APA：
Deng Xun,Cheng Yong,Zhu Xue-Mei,Linghu Dan-Dan,Xu Hua&Liang Jian-Hong.(2022).Foveal structure changes in infants treated with anti-VEGF therapy or laser therapy guided by optical coherence tomography angiography for retinopathy of prematurity..International Journal of Ophthalmology,15,(1)
MLA：
Deng Xun,et al."Foveal structure changes in infants treated with anti-VEGF therapy or laser therapy guided by optical coherence tomography angiography for retinopathy of prematurity.".International Journal of Ophthalmology 15..1(2022):106-112
