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Vision Prognosis and Associated Factors of Optic Neuritis in Dependence of Glial Autoimmune Antibodies.

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机构： [1]Department of Ophthalmology, The Chinese People’s Liberation Army General Hospital & The Chinese People’s Liberation Army Medical School ,Beijing, China [2]Department of Neuro-ophthalmology, Eye Hospital, China Academy of Chinese Medical Sciences ,Beijing, China [3]Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center,Beijing, China [4]Department of Ophthalmology, the 980th Hospital of the Chinese PLA Joint Logistics Support Force,Shijiazhuang, Hebei, China [5]Shantou University Medical College ,Shantou, China [6]Beijing MEM DINGHUI Hospital Co. Ltd ,Beijing, China [7]Department of Neurology, the First Medical Center of Chinese PLA General Hospital,Beijing, China [8]Department of Ophthalmology, Medical Faculty Mannheim, Heidelberg University,Germany [9]Institute of Molecular and Clinical Ophthalmology,Basel, Switzerland [10]Privatpraxis Prof Jonas und Dr Panda-Jonas,Heidelberg, Germany

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To assess the visual prognosis of optic neuritis (ON) in dependence of the glial autoimmune antibody status and associated factors.Longitudinal observational cohort study METHODS: : Patients with ON and measurements of serum concentrations of glial autoantibodies were consecutively and longitudinally examined with a minimal follow-up of three months. Patients with multiple sclerosis and double seronegative results were excluded.The study included 529 patients (aquaporin-4 immunoglobulin (AQP4-IgG) seropositive,n=291;myelin oligodendrocyte glycoprotein immunoglobulin (MOG-IgG) seropositive,n=112;double-seronegative,n=126) with 1022 ON episodes (AQP4-IgG seropositive,n=550;MOG-IgG seropositive,n=254;double-seronegative,n=218). Prevalence of severe vision loss (best-corrected visual acuity (BCVA) ≤20/200 at the end of follow-up) was higher (P<0.001) in the AQP4-IgG group (236/550;42.9%) than in the seronegative group (68/218;31.2%) and in the MOG-IgG group (15/254;5.9%). Prevalence of good vision recovery (BCVA≥20/40) was higher (P<0.001) in the MOG-IgG group (229/254;90.2%) than in the seronegative group (111/218:50.9%) and in the AQP4-IgG group (236/550;42.9%). In multivariable logistic analysis, higher prevalence of severe vision loss was associated with AQP4-IgG seropositivity (odds ratio (OR):1.66;95% confidence interval (CI):1.14,2.43;P=0.008), male sex (OR:1.97;95%CI:1.33,2.93;P<0.001), age at ON onset >45 years (OR:1.93;95%CI:1.35,2.77;P<0.001), nadir vision ≤20/200 (OR:14.11;95%CI:6.54,36.93;P<0.001) and higher number of recurrences (OR:1.35;95%CI:1.14,1.61;P=0.001). Higher prevalence of good vision outcome was associated with MOG-IgG seropositivity (OR:8.13;95%CI:4.82,14.2;P<0.001), age at ON onset <18 years (OR:1.78;95%CI:1.18,2.71;P=0.006), nadir visual acuity ≥20/40 (OR:4.03;95%CI:1.45,14.37;P=0.015) and lower number of recurrences (OR:0.60;95%CI:0.50,0.72;P<0.001).Severe vision loss (prevalence in the AQP4-IgG group, MOG-IgG group and seronegative group:42.9%,5.9%, and 31.2%, respectively) was associated with AQP4-IgG seropositivity, male gender, older age at onset, worse nadir vision, and higher number of recurrences.Copyright © 2022. Published by Elsevier Inc.

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大类 | 2 区

医学

小类 | 1 区眼科学

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大类 | 1 区

医学

小类 | 1 区眼科学

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第一作者机构： [2]Department of Neuro-ophthalmology, Eye Hospital, China Academy of Chinese Medical Sciences ,Beijing, China

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通讯机构： [1]Department of Ophthalmology, The Chinese People’s Liberation Army General Hospital & The Chinese People’s Liberation Army Medical School ,Beijing, China [*1]Department of Ophthalmology, The Chinese People’s Liberation Army General Hospital & The Chinese People’s Liberation Army Medical School, Beijing 100853, China

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