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Novel insights into the roles and therapeutic implications of MUC1 oncoprotein via regulating proteins and non-coding RNAs in cancer.

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机构： [1]Department of Urology, Shanghai Tenth People's Hospital, Tongji University, Shanghai, China. [2]Urologic Cancer Institute, Tongji University School of Medicine, Shanghai, China. [3]Department of Orthodontics, Peking University School and Hospital of Stomatology, Beijing, China. [4]Department of Anesthesiology, Tongren Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, P. R. China. [5]Department of Pathology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China. [6]Department of Urology, RenJi Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China. [7]Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA.

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Mucin 1 (MUC1) is a heterodimeric transmembrane glycoprotein that protects epithelial cells in mammals. The transmembrane C-terminal subunit (MUC1-C) plays a crucial role in oncogenesis. As an oncoprotein, MUC1-C regulates a number of proteins that are associated with tumorigenesis by interacting with oncoproteins, transcription factors, coactivators, etc., inducing proliferation, epithelial-mesenchymal transition (EMT), invasion, stemness, immune evasion, and drug resistance. Moreover, MUC1-C modulates the expression of non-coding RNAs (ncRNAs), which further regulate carcinogenesis by directly binding to specific proteins. ncRNAs can also affect MUC1 protein expression by targeting the MUC1 mRNA 3' untranslated region (UTR). A series of ncRNAs can modulate cancer development by regulating MUC1-C. This review focuses on the interaction of MUC1-C with proteins and ncRNAs in cancer progression. We also summarize the recent advances in immunotherapy with a focus on therapeutic approaches based on MUC1-C and nanocarrier complexes for cancer treatment.© The author(s).

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出版当年[2021]版：

大类 | 1 区

医学

小类 | 1 区医学：研究与实验

最新[2023]版：

大类 | 1 区

医学

小类 | 1 区医学：研究与实验

第一作者：

第一作者机构： [1]Department of Urology, Shanghai Tenth People's Hospital, Tongji University, Shanghai, China. [2]Urologic Cancer Institute, Tongji University School of Medicine, Shanghai, China. [*1]Department of Urology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, No.301 Yanchang Road, Jing'an District, Shanghai, 200072 China.

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通讯作者：

通讯机构： [1]Department of Urology, Shanghai Tenth People's Hospital, Tongji University, Shanghai, China. [2]Urologic Cancer Institute, Tongji University School of Medicine, Shanghai, China. [7]Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA. [*1]Department of Urology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, No.301 Yanchang Road, Jing'an District, Shanghai, 200072 China. [*2]Department of Urology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, No.301 Yanchang Road, Jing'an District, Shanghai, 200072 China [*3]Dana-Farber Cancer Institute, Harvard Medical School, 450 Brookline Avenue, D830, Boston, Massachusetts, USA

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