机构：[1]Beijing Tongren Eye Center, Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China首都医科大学附属北京同仁医院研究所眼科研究所[2]School of Physics and Optoelectronic Engineering, Foshan University, Foshan 528000, China[3]Department of Ophthalmology, University of Washington, Seattle, WA 98195, USA
(1) Background: To investigate the value of pulsatile trabecular meshwork (TM) motion in predicting the diurnal intraocular pressure (IOP) fluctuation of primary open-angle glaucoma (POAG). (2) Methods: This cross-sectional study recruited 20 normal patients and 30 patients with POAG. Of the POAG group, 20 had stable diurnal IOP and 10 had high IOP fluctuation. A clinical prototype phase-sensitive optical coherence tomography (PhS-OCT) model was used to measure TM pulsatile motion with maximum velocity (MV) and cumulative displacement (CDisp). (3) Results: MV and CDisp were higher in the external region in both normal and POAG patients. All MV and CDisp reduced significantly in the POAG group (p < 0.001). In the POAG group, except MV in the external region (p = 0.085), MV and CDisp in the nasal area were significantly higher than those in the temporal area (p < 0.05). The MV and CDisp in the external region in the nasal area of POAG patients with high IOP fluctuation were much lower than those with stable IOP (p(EMV3) = 0.031, p(ECDisp3) < 0.001); (4) Conclusions: Pulsatile TM motion reduced in POAG patients relevant to the level of diurnal IOP fluctuation. This study presents the segmental variance of TM stiffness in human living eyes and suggests the clinical potential of the measurement of pulsatile TM motion with PhS-OCT for the evaluation of diurnal IOP fluctuation.
基金：
Supported by the Open Research Fund from Beijing Advanced Innovation Center for Big
Data-Based Precision Medicine, Beijing Tongren Hospital, Beihang University & Capital Medical
University, Grant No. 202012 (BHTR-KFJJ-202012).
第一作者机构：[1]Beijing Tongren Eye Center, Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China
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通讯作者：
推荐引用方式(GB/T 7714)：
Du Rong,Xin Chen,Xu Jingjiang,et al.Pulsatile Trabecular Meshwork Motion: An Indicator of Intraocular Pressure Control in Primary Open-Angle Glaucoma[J].JOURNAL OF CLINICAL MEDICINE.2022,11(10):doi:10.3390/jcm11102696.
APA：
Du, Rong,Xin, Chen,Xu, Jingjiang,Hu, Jianping,Wang, Huaizhou...&Johnstone, Murray.(2022).Pulsatile Trabecular Meshwork Motion: An Indicator of Intraocular Pressure Control in Primary Open-Angle Glaucoma.JOURNAL OF CLINICAL MEDICINE,11,(10)
MLA：
Du, Rong,et al."Pulsatile Trabecular Meshwork Motion: An Indicator of Intraocular Pressure Control in Primary Open-Angle Glaucoma".JOURNAL OF CLINICAL MEDICINE 11..10(2022)
