机构：[1]Department of Cardiology, Renmin Hospital, School of Basic Medical Science, Wuhan University, Wuhan, China[2]Institute of Model Animal, Wuhan University, Wuhan, China[3]Eye Center, Renmin Hospital of Wuhan University, Wuhan, China[4]Medical Science Research Center, Zhongnan Hospital of Wuhan University, Wuhan, China[5]Department of general surgery, Huanggang Central Hospital, Wuhan, China[6]Department of Neurology, Wuhan First Hospital/Wuhan Hospital of Traditional Chinese and Western Medicine, Wuhan, China[7]Department of Hepatobiliary Surgery, The First Affiliated Hospital of Changjiang University, Jingzhou, China[8]Department of Hepatobiliary Surgery, Jingzhou Central Hospital, Jingzhou, China[9]Department of Hepatobiliary and Pancreatic Surgery, Xianning Central Hospital, Xianning, China[10]Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, China[11]Department of Cardiology, The First College of Clinical Medical Science, China Three Gorges University and Yichang Central People’s Hospital and Institute of Cardiovascular Diseases, China Three Gorges University, Yichang, China[12]Department of Gastroenterology, Wuhan Third Hospital and Tongren Hospital of Wuhan University, Wuhan, China[13]Department of Neonatology, Renmin Hospital of Wuhan University, Wuhan, China[14]Department of Hepatobiliary and Pancreatic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, China[15]Department of Cardiology, The Third Xiangya Hospital, Central South University, Changsha, China[16]Department of Anesthesiology, Cardiovascular Research Laboratories, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA
Background: The coronavirus disease 2019 (COVID-19) is a recently emerged respiratory infectious disease with kidney injury as a part of the clinical complications. However, the dynamic change of kidney function and its association with COVID-19 prognosis are largely unknown. Methods: In this multicenter retrospective cohort study, we analyzed clinical characteristics, medical history, laboratory tests, and treatment data of 12,413 COVID-19 patients. The patient cohort was stratified according to the severity of the outcome into three groups: non-severe, severe, and death. Findings: The prevalence of elevated blood urea nitrogen (BUN), elevated serum creatinine (Scr), and decreased blood uric acid ( BUA) at admission was 6.29%, 5.22%, and 11.66%, respectively. The trajectories showed the elevation in BUN and Scr levels, as well as a reduction in BUA level for 28 days after admission in death cases. Increased all cause mortality risk was associated with elevated baseline levels of BUN and Scr and decreased levels of BUA. Conclusions: The dynamic changes of the three kidney function markers were associated with different severity and poor prognosis of COVID-19 patients. BUN showed a close association with and high potential for predicting adverse outcomes in COVID-19 patients for severity stratification and triage.
基金：
This study was supported by grants from the National Key
R&D Program of China (2016YFF0101504), the National Science Foundation
of China (81630011, 81970364, 81970070, 81970011, 81870171,
and 81700356), the Major Research Plan of the National Natural Science
Foundation of China (91639304), the Hubei Science and Technology
Support Project (2019BFC582, 2018BEC473, and 2017BEC001), and
the Medical Flight Plan of Wuhan University.
第一作者机构：[1]Department of Cardiology, Renmin Hospital, School of Basic Medical Science, Wuhan University, Wuhan, China[2]Institute of Model Animal, Wuhan University, Wuhan, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Cardiology, Renmin Hospital, School of Basic Medical Science, Wuhan University, Wuhan, China[2]Institute of Model Animal, Wuhan University, Wuhan, China[4]Medical Science Research Center, Zhongnan Hospital of Wuhan University, Wuhan, China[12]Department of Gastroenterology, Wuhan Third Hospital and Tongren Hospital of Wuhan University, Wuhan, China
推荐引用方式(GB/T 7714)：
Liu Ye-Mao,Xie Jing,Chen Ming-Ming,et al.Kidney Function Indicators Predict Adverse Outcomes of COVID-19[J].MED.2021,2(1):38-+.doi:10.1016/j.medj.2020.09.001.
APA：
Liu, Ye-Mao,Xie, Jing,Chen, Ming-Ming,Zhang, Xiao,Cheng, Xu...&Li, Hongliang.(2021).Kidney Function Indicators Predict Adverse Outcomes of COVID-19.MED,2,(1)
MLA：
Liu, Ye-Mao,et al."Kidney Function Indicators Predict Adverse Outcomes of COVID-19".MED 2..1(2021):38-+
医学