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Autophagy: A Novel Horizon for Hair Cell Protection

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机构: [1]Fudan Univ, ENT Inst, Shanghai 200031, Peoples R China [2]Fudan Univ, Otorhinolaryngol Dept, Eye & ENT Hosp, State Key Lab Med Neurobiol, Shanghai 200031, Peoples R China [3]Fudan Univ, NHC Key Lab Hearing Med, Shanghai 200031, Peoples R China [4]Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Dept Otorhinolaryngol, 600 Yishan Rd, Shanghai 200233, Peoples R China [5]Southeast Univ, Nanjing Tongren Hosp, Sch Med, Dept Otolaryngol Head & Neck, Nanjing, Peoples R China
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As a general sensory disorder, hearing loss was a major concern worldwide. Autophagy is a common cellular reaction to stress that degrades cytoplasmic waste through the lysosome pathway. Autophagy not only plays major roles in maintaining intracellular homeostasis but is also involved in the development and pathogenesis of many diseases. In the auditory system, several studies revealed the link between autophagy and hearing protection. In this review, we aimed to establish the correlation between autophagy and hair cells (HCs) from the aspects of ototoxic drugs, aging, and acoustic trauma and discussed whether autophagy could serve as a potential measure in the protection of HCs.

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出版当年[2020]版:
大类 | 3 区 医学
小类 | 3 区 神经科学
最新[2025]版:
大类 | 3 区 医学
小类 | 4 区 神经科学
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Q2 NEUROSCIENCES
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Q2 NEUROSCIENCES

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第一作者机构: [1]Fudan Univ, ENT Inst, Shanghai 200031, Peoples R China [2]Fudan Univ, Otorhinolaryngol Dept, Eye & ENT Hosp, State Key Lab Med Neurobiol, Shanghai 200031, Peoples R China [3]Fudan Univ, NHC Key Lab Hearing Med, Shanghai 200031, Peoples R China
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通讯机构: [1]Fudan Univ, ENT Inst, Shanghai 200031, Peoples R China [2]Fudan Univ, Otorhinolaryngol Dept, Eye & ENT Hosp, State Key Lab Med Neurobiol, Shanghai 200031, Peoples R China [3]Fudan Univ, NHC Key Lab Hearing Med, Shanghai 200031, Peoples R China
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