As a general sensory disorder, hearing loss was a major concern worldwide. Autophagy is a common cellular reaction to stress that degrades cytoplasmic waste through the lysosome pathway. Autophagy not only plays major roles in maintaining intracellular homeostasis but is also involved in the development and pathogenesis of many diseases. In the auditory system, several studies revealed the link between autophagy and hearing protection. In this review, we aimed to establish the correlation between autophagy and hair cells (HCs) from the aspects of ototoxic drugs, aging, and acoustic trauma and discussed whether autophagy could serve as a potential measure in the protection of HCs.
基金:
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [82071045, 81870728]; Shanghai Rising-Star Program [19QA1401800]
第一作者机构:[1]Fudan Univ, ENT Inst, Shanghai 200031, Peoples R China[2]Fudan Univ, Otorhinolaryngol Dept, Eye & ENT Hosp, State Key Lab Med Neurobiol, Shanghai 200031, Peoples R China[3]Fudan Univ, NHC Key Lab Hearing Med, Shanghai 200031, Peoples R China
共同第一作者:
通讯作者:
通讯机构:[1]Fudan Univ, ENT Inst, Shanghai 200031, Peoples R China[2]Fudan Univ, Otorhinolaryngol Dept, Eye & ENT Hosp, State Key Lab Med Neurobiol, Shanghai 200031, Peoples R China[3]Fudan Univ, NHC Key Lab Hearing Med, Shanghai 200031, Peoples R China
推荐引用方式(GB/T 7714):
Liu Chang,Zheng Zhiwei,Wang Pengjun,et al.Autophagy: A Novel Horizon for Hair Cell Protection[J].NEURAL PLASTICITY.2021,2021:doi:10.1155/2021/5511010.
APA:
Liu, Chang,Zheng, Zhiwei,Wang, Pengjun,He, Shuangba&He, Yingzi.(2021).Autophagy: A Novel Horizon for Hair Cell Protection.NEURAL PLASTICITY,2021,
MLA:
Liu, Chang,et al."Autophagy: A Novel Horizon for Hair Cell Protection".NEURAL PLASTICITY 2021.(2021)