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The Immune Microenvironment in Brain Metastases of Non-Small Cell Lung Cancer

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机构： [1]Fudan Univ, Shanghai Canc Ctr, Dept Radiat Oncol, Shanghai, Peoples R China [2]Fudan Univ, Shanghai Med Coll, Dept Oncol, Shanghai, Peoples R China [3]Shanghai Jiao Tong Univ, Sch Med, TongRen Hosp, Dept Orthoped, Shanghai, Peoples R China

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关键词： immune microenvironment brain metastases non-small cell lung cancer immune therapeutics brain metastases of non-small cell lung cancer

摘要：

Brain metastasis of non-small cell lung cancer is associated with poor survival outcomes and poses rough clinical challenges. At the era of immunotherapy, it is urgent to perform a comprehensive study uncovering the specific immune microenvironment of brain metastases of NSCLC. The immune microenvironment of brain is distinctly different from microenvironments of extracranial lesions. In this review, we summarized the process of brain metastases across the barrier and revealed that brain is not completely immune-privileged. We comprehensively described the specific components of immune microenvironment for brain metastases such as central nervous system-derived antigen-presenting cells, microglia and astrocytes. Besides, the difference of immune microenvironment between brain metastases and primary foci of lung was particularly demonstrated.

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出版当年[2020]版：

大类 | 2 区医学

小类 | 3 区肿瘤学

最新[2023]版：

大类 | 3 区医学

小类 | 3 区肿瘤学

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出版当年[2019]版：

Q2 ONCOLOGY

最新[2023]版：

Q2 ONCOLOGY

影响因子： 3.5 最新[2023版] 4 最新五年平均 4.848 出版当年[2019版] 0 出版当年五年平均 4.137 出版前一年[2018版] 6.244 出版后一年[2020版]

第一作者：

第一作者机构： [1]Fudan Univ, Shanghai Canc Ctr, Dept Radiat Oncol, Shanghai, Peoples R China [2]Fudan Univ, Shanghai Med Coll, Dept Oncol, Shanghai, Peoples R China

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通讯作者：

通讯机构： [1]Fudan Univ, Shanghai Canc Ctr, Dept Radiat Oncol, Shanghai, Peoples R China [2]Fudan Univ, Shanghai Med Coll, Dept Oncol, Shanghai, Peoples R China

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