Objective: To study the combined toxicity of chrysanthemum extract (CME) and high dose cadmium chloride (Cd) in multiple organs after maternal exposure to CME, Cd and CME+Cd. Method: An extended one-generation rat reproductive toxicity was carried out, and animals were divided into four groups: the control group, CME-fed group (3 g/kg), Cd-fed group (20 mg/kg), and CME+Cd-fed group (3 g/kg CME and 20 mg/kg Cd). Rats were exposed to Cd and CME+Cd during pregnancy and lactation, discontinued after weaning, and exposed to CME throughout the experiment. Result: CME didn't induce adverse effects; Cadmium and CME+Cd caused body weight loss, hematologic and cardiac toxicity, renal and liver toxicity, offspring skeletal muscle inflammation; CME+Cd toxicity was more severe than Cd, in maternal and offsprings' body weight and maternal ovary, maternal hematologic and cardiac toxicity, male offspring renal toxicity, and female offspring cardiac toxicity. Conclusion: Cd and CME induced combined reproductive and developmental toxicity, CME aggravated Cd toxicity, in early life stage with high level Cd exposure.