机构：[1]Basic Medical Institute Hongqiao International Institute of Medicine, Tongren Hospital Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, China[2]Department of Gastroenterlogy, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai, China.[3]Department of gastroenterology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Tryptophan metabolism is an essential regulator of tumor immune evasion. However, the effect of tryptophan metabolism on cancer cells remains largely unknown. Here, we find that tumor cells have distinct responses to tryptophan deficiency in terms of cell growth, no matter hepatocellular carcinoma (HCC) cells, lung cancer cells, or breast cancer cells. Further study shows that ERRFI1 is upregulated in sensitive HCC cells, but not in resistant HCC cells, in response to tryptophan deficiency, and ERRFI1 expression level positively correlates with HCC patient overall survival. ERRFI1 knockdown recovers tryptophan deficiency-suppressed cell growth of sensitive HCC cells. In contrast, ERRFI1 overexpression sensitizes resistant HCC cells to tryptophan deficiency. Moreover, ERRFI1 induces apoptosis by binding PDCD2 in HCC cells, PDCD2 knockdown decreases the ERRFI1-induced apoptosis in HCC cells. Thus, we conclude that ERRFI1-induced apoptosis increases the sensitivity of HCC cells to tryptophan deficiency and ERRFI1 interacts with PDCD2 to induce apoptosis in HCC cells.
基金：
National Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81872342, 82073040]; National Science and Technology Major Project [2018YFC1313205]
第一作者机构：[1]Basic Medical Institute Hongqiao International Institute of Medicine, Tongren Hospital Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, China
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Cui Mingqing,Liu Dan,Xiong Wujun,et al.ERRFI1 induces apoptosis of hepatocellular carcinoma cells in response to tryptophan deficiency[J].CELL DEATH DISCOVERY.2021,7(1):doi:10.1038/s41420-021-00666-y.
APA：
Cui, Mingqing,Liu, Dan,Xiong, Wujun,Wang, Yugang&Mi, Jun.(2021).ERRFI1 induces apoptosis of hepatocellular carcinoma cells in response to tryptophan deficiency.CELL DEATH DISCOVERY,7,(1)
MLA：
Cui, Mingqing,et al."ERRFI1 induces apoptosis of hepatocellular carcinoma cells in response to tryptophan deficiency".CELL DEATH DISCOVERY 7..1(2021)
生物学