机构:[1]Beijing Institute of Ophthalmology,Department of Ophthalmology,Beijing Tongren Hospital,Capital Medical University,China首都医科大学附属北京同仁医院临床科室眼科眼底科眼科(未分亚科)研究所眼科研究所[2]Beijing Retinal and Choroidal Vascular Study Group, China[3]Save Sight Institute, University of Sydney, Australia
Cholesterol esters, synthesized from cholesterol with long-chain fatty acids, are essential components of plasma lipoproteins and cell membranes that participate in various metabolic processes in the body. Cholesterol can be excreted through the cholesterol reverse transport (RCT) pathway when excessive cholesterol is produced in the extrahepatic cells, which is regulated by the liver X receptor (LXR) and its downstream regulators ATP-binding cassette subfamily A member 1 (ABCA1) and ATP-binding cassette subfamily G member 1 (ABCG1) genes. Abnormal cholesterol metabolism is closely associated with the development of diabetic retinopathy (DR). However, the precise underlying mechanism of the RCT pathway in the pathogenesis of DR is still not fully understood. This review focused on cholesterol metabolism, with a particular emphasis on the RCT pathway and its correlation with the development of DR. Particular attention has been paid to the key regulators of the RCT pathway: LXR, ABCA1, and ABCG1 genes and their potential therapeutic targets in the management of DR.</p>
基金:
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81570850, 81170859, 82070988]; Ministry of Science and Technology Foundation of China [2016YFC1305604]
语种:
外文
被引次数:
WOS:
PubmedID:
中科院(CAS)分区:
出版当年[2020]版:
大类|3 区医学
小类|3 区医学:研究与实验4 区内分泌学与代谢
最新[2023]版:
大类|3 区医学
小类|3 区内分泌学与代谢3 区医学:研究与实验
JCR分区:
出版当年[2019]版:
Q3ENDOCRINOLOGY & METABOLISMQ3MEDICINE, RESEARCH & EXPERIMENTAL
最新[2023]版:
Q2ENDOCRINOLOGY & METABOLISMQ2MEDICINE, RESEARCH & EXPERIMENTAL
第一作者机构:[1]Beijing Institute of Ophthalmology,Department of Ophthalmology,Beijing Tongren Hospital,Capital Medical University,China[2]Beijing Retinal and Choroidal Vascular Study Group, China
通讯作者:
通讯机构:[1]Beijing Institute of Ophthalmology,Department of Ophthalmology,Beijing Tongren Hospital,Capital Medical University,China[2]Beijing Retinal and Choroidal Vascular Study Group, China
推荐引用方式(GB/T 7714):
Zhang Xinyuan,Wang Kaiyue,Zhu Ling,et al.Reverse Cholesterol Transport Pathway and Cholesterol Efflux in Diabetic Retinopathy[J].JOURNAL OF DIABETES RESEARCH.2021,2021:doi:10.1155/2021/8746114.
APA:
Zhang, Xinyuan,Wang, Kaiyue,Zhu, Ling&Wang, Qiyun.(2021).Reverse Cholesterol Transport Pathway and Cholesterol Efflux in Diabetic Retinopathy.JOURNAL OF DIABETES RESEARCH,2021,
MLA:
Zhang, Xinyuan,et al."Reverse Cholesterol Transport Pathway and Cholesterol Efflux in Diabetic Retinopathy".JOURNAL OF DIABETES RESEARCH 2021.(2021)