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Reverse Cholesterol Transport Pathway and Cholesterol Efflux in Diabetic Retinopathy

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机构: [1]Beijing Institute of Ophthalmology,Department of Ophthalmology,Beijing Tongren Hospital,Capital Medical University,China [2]Beijing Retinal and Choroidal Vascular Study Group, China [3]Save Sight Institute, University of Sydney, Australia
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Cholesterol esters, synthesized from cholesterol with long-chain fatty acids, are essential components of plasma lipoproteins and cell membranes that participate in various metabolic processes in the body. Cholesterol can be excreted through the cholesterol reverse transport (RCT) pathway when excessive cholesterol is produced in the extrahepatic cells, which is regulated by the liver X receptor (LXR) and its downstream regulators ATP-binding cassette subfamily A member 1 (ABCA1) and ATP-binding cassette subfamily G member 1 (ABCG1) genes. Abnormal cholesterol metabolism is closely associated with the development of diabetic retinopathy (DR). However, the precise underlying mechanism of the RCT pathway in the pathogenesis of DR is still not fully understood. This review focused on cholesterol metabolism, with a particular emphasis on the RCT pathway and its correlation with the development of DR. Particular attention has been paid to the key regulators of the RCT pathway: LXR, ABCA1, and ABCG1 genes and their potential therapeutic targets in the management of DR.</p>

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出版当年[2020]版:
大类 | 3 区 医学
小类 | 3 区 医学:研究与实验 4 区 内分泌学与代谢
最新[2023]版:
大类 | 3 区 医学
小类 | 3 区 内分泌学与代谢 3 区 医学:研究与实验
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出版当年[2019]版:
Q3 ENDOCRINOLOGY & METABOLISM Q3 MEDICINE, RESEARCH & EXPERIMENTAL
最新[2023]版:
Q2 ENDOCRINOLOGY & METABOLISM Q2 MEDICINE, RESEARCH & EXPERIMENTAL

影响因子: 最新[2023版] 最新五年平均 出版当年[2019版] 出版当年五年平均 出版前一年[2018版] 出版后一年[2020版]

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第一作者机构: [1]Beijing Institute of Ophthalmology,Department of Ophthalmology,Beijing Tongren Hospital,Capital Medical University,China [2]Beijing Retinal and Choroidal Vascular Study Group, China
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通讯机构: [1]Beijing Institute of Ophthalmology,Department of Ophthalmology,Beijing Tongren Hospital,Capital Medical University,China [2]Beijing Retinal and Choroidal Vascular Study Group, China
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