Hepatocellular carcinoma (HCC) is a common malignancy in human. CD44 is a transmembrane glycoprotein which is frequently overexpressed in cancer of various origins. The function and mechanism of CD44 in HCC remains elusive. In this study, we reported that CD44 was overexpressed in HCC to promote the proliferation and migration of HCC cells via oncogenic YAP, which is the key downstream regulator in Hippo pathway. These findings suggest that CD44-YAP is a probable important axis in pathogenesis of HCC, providing an insight in to HCC pathogenesis as well as potential targets for the intervention of HCC.
基金：
“Transformation Medicine Cross Research
Fund” (Grant No.: ZH2018QNB25 to W. Zhao), the National Natural Science
Foundation of China (Grant No.: 81974447 & 81572712 to L. Chen), the Natural
Science Fund for Distinguished Young Scholars of Jiangsu Province (Grant No.: BK20200035 to L. Chen), and the Priority Academic Program Development of
Jiangsu Higher Education Institutions.
