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Pathological Consequences of Reduced Cerebrospinal Fluid Pressure: Experimental Studies

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机构： [1]Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China.Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing, China [2]Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing, China

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It has been speculated that a low orbital cerebrospinal fluid pressure (CSFP) may perhaps play a role in the pathogenesis of glaucomatous optic neuropathy. To verify the hypothesis, we conducted a serial of experimental study on low-CSFP models of monkeys and rats. Our studies showed that a reduction in CSFP could result in the structural and physiological changes of optic nerve and some molecular biology reactions in the optic axons. We hope that our chapter will be helpful for the further research in the pathogenesis of glaucoma.

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第一作者机构： [1]Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China.Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing, China

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