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Long-term outcomes of transarterial embolization with lipiodol-bleomycin emulsion plus polyvinyl alcohol particles versus the particles alone for large symptomatic focal nodular hyperplasia: a propensity score-matched analysis

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机构: [1]Chinese Peoples Liberat Army Gen Hosp, Dept Intervent Radiol, Beijing 100853, Peoples R China [2]Capital Med Univ, Beijing Tongren Hosp, Dept Radiol, Beijing 100730, Peoples R China [3]Chinese Peoples Liberat Army Gen Hosp, Med Ctr 2, Dept Radiol, Beijing, Peoples R China [4]Chinese Peoples Liberat Army Gen Hosp, Dept Diagnost Radiol, Beijing 100853, Peoples R China [5]Chinese Peoples Liberat Army Gen Hosp, Dept Hepatobiliary Surg, Beijing 100853, Peoples R China [6]Air Force Med Ctr PLA, Dept Med Imaging, Beijing, Peoples R China [7]Chinese Peoples Liberat Army Gen Hosp, Med Ctr 2, Hlth Care Dept 1, Beijing 100853, Peoples R China [8]Chinese Peoples Liberat Army Gen Hosp, Natl Clin Res Ctr Geriatr Dis, Beijing 100853, Peoples R China
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关键词: Angiography Focal nodular hyperplasia Liver neoplasms Radiology Therapeutic

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Objectives To compare the efficacy of transarterial embolization (TAE) with polyvinyl alcohol (PVA) particles alone and lipiodol-bleomycin emulsion (LBE) plus PVA particles for patients with unresectable large symptomatic focal nodular hyperplasia (FNH). Methods We performed a retrospective analysis of patients who underwent TAE either with PVA particles alone (group A, n = 46) or LBE plus PVA particles (group B, n = 35) for large (>= 7 cm) symptomatic FNH between January 2002 and February 2019. Propensity score matching (PSM) (1:1) was performed to adjust for potential baseline confounders. Technical success, adverse events (AEs), symptom relief, and changes in the lesion size after TAE were evaluated. Statistical analysis included Wilcoxon rank sum test and chi(2) test. Results After PSM, no significant differences in baseline characteristics were found between the groups (31 in group A and 31 in group B, with a mean age of 31 years). Technical success was achieved in all patients (100%), without major AEs in both groups. Complete resolution of the abdominal symptoms was reported in 77.4% in group A and 100% in group B (p = 0.037) during a mean follow-up period of 72 months; complete resolution (CR) of the FNH rate was significantly higher in group B than in group A (93.6% vs. 67.7%; p = 0.019). Conclusion Compared with the use PVA particles alone, TAE with LBE plus PVA particles in the treatment of patients with large symptomatic FNH had a significantly higher rates of CR of the FNH and complete relief of the symptoms.

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出版当年[2021]版:
大类 | 2 区 医学
小类 | 2 区 核医学
最新[2023]版:
大类 | 2 区 医学
小类 | 2 区 核医学
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出版当年[2020]版:
Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
最新[2023]版:
Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

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第一作者机构: [1]Chinese Peoples Liberat Army Gen Hosp, Dept Intervent Radiol, Beijing 100853, Peoples R China
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