机构：[1]Department of Physiology, Faculty of Basic Medical Sciences, Guilin Medical University, Guilin, China[2]Department of Pathology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China[3]Graduate School of Guilin Medical University, Guilin, China[4]Department of Pathology, the Second Affiliated Hospital, Guilin Medical University, Guilin, China[5]Guangxi Health Commission Key Laboratory of Glucose and Lipid Metabolism Disorders, Guilin, China
Streptozotocin (STZ)-induced diabetes rodent models are widely used to study the pathogenesis and metabolic function in diabetes (DM). The aim of this study was to assess the antioxidant effect of curcumin in STZ-induced type 2 diabetes mellitus (T2DM). In this research, rats were randomly divided into 3 groups (8 in each group): a nondiabetic group (Control), a diabetic group (DM), and a curcumin treatment group (DM + Cur 200 mg/kg group). Meanwhile, after intraperitoneal injection (i.p.), associated-oxidative stress parameters were observed, malondialdehyde (MDA) was decreased, and glutathione peroxidase (GPX) and super oxide dismutase (SOD) were restored in pancreatic tissues of curcumin-treated DM rats. In addition, curcumin improved the survival and function of islet cells with decreased cell apoptosis in Langerhans islet and increased insulin secretion in the STZ-induced T2DM rat model. Our findings suggest that curcumin is a potent candidate for the prevention and therapy of DM.
基金：
the National Natural
Foundation Science of China (NSFC 8176100494).
第一作者机构：[1]Department of Physiology, Faculty of Basic Medical Sciences, Guilin Medical University, Guilin, China[2]Department of Pathology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Physiology, Faculty of Basic Medical Sciences, Guilin Medical University, Guilin, China[4]Department of Pathology, the Second Affiliated Hospital, Guilin Medical University, Guilin, China[5]Guangxi Health Commission Key Laboratory of Glucose and Lipid Metabolism Disorders, Guilin, China[*1]Department of Physiology, Faculty of Basic Medical Science, Guilin Medical University, Zhiyuan Road, Guilin, Guangxi Province 541004, People’s Republic of China[*2]Department of Pathology, the Second Affiliated Hospital, Guilin Medical University, 212 Renmin Road, Lingui District, Guilin, Guangxi Province 541199, People’s Republic of China
推荐引用方式(GB/T 7714)：
Duan Jingling,Yang Mingqing,Liu Yi,et al.Curcumin protects islet beta cells from streptozotocin‑induced type 2 diabetes mellitus injury via its antioxidative effects[J].ENDOKRYNOLOGIA POLSKA.2022,73(6):942-946.doi:10.5603/EP.a2022.0070.
APA：
Duan Jingling,Yang Mingqing,Liu Yi,Xiao Shengjun&Zhang Xiaoling.(2022).Curcumin protects islet beta cells from streptozotocin‑induced type 2 diabetes mellitus injury via its antioxidative effects.ENDOKRYNOLOGIA POLSKA,73,(6)
MLA：
Duan Jingling,et al."Curcumin protects islet beta cells from streptozotocin‑induced type 2 diabetes mellitus injury via its antioxidative effects".ENDOKRYNOLOGIA POLSKA 73..6(2022):942-946
