Objectives Major ocular diseases share common risk factors and pathogeneses with stroke. This study aimed to evaluate the relation between stroke and ocular diseases including visual impairment (VI). Methods The cross-sectional study investigated the prevalence and associations of VI and major eye diseases with stroke among 4570 participants in the 2005-2008 National Health and Nutrition Examination Survey (NHANES). The association of VI and major ocular diseases with stroke were estimated using univariate and multivariate logistic regression crude models and models adjusted for demographics and clinical factors. We also conducted stratified analyses by diabetes and hypertension status. Results VI was associated with stroke, and the odds ratios (ORs) for mild and moderate and severe visual impairment (MSVI) were 6.79 (95% confidence interval (CI): 2.44-18.88) and 9.46 (95% CI: 2.19-40.94) after adjusting for age and gender (all P < 0.05). Ocular disease was associated with stroke with OR reaching 5.54 (95% CI: 1.83-16.74), and the OR was 9.61 (95% CI: 3.05-30.23) for stroke patients suffering DR after adjusting for age and gender (all P < 0.05). After multivariable adjustment, the associations were limited to mild VI (OR = 10.00, 95% CI: 3.16-30.58), MSVI (OR = 8.57, 95% CI: 1.58-43.36), and any ocular disease (OR = 5.18, 95% CI: 1.46-18.42) (all P < 0.05). Significant associations between stroke and any ocular disease and DR were observed among diabetic participants, and significant relation between stroke and MSVI was found among hypertension patients. Conclusions The sample of the US population demonstrates significant associations between VI and major ocular disease with stroke.
基金:
National Natural Science Foundation of China [82141128]; Capital Health Research and Development of Special [2020-1-2052]; Science & Technology Project of Beijing Municipal Science & Technology Commission [Z201100005520045, Z181100001818003]
第一作者机构:[1]Capital Med Univ, Beijing Tongren Hosp,Beijing Tongren Eye Ctr,Beij, Minist Ind & Informat Technol,Beijing Ophthalmol, Med Artificial Intelligence Res & Verificat Key L, Beijing, Peoples R China
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推荐引用方式(GB/T 7714):
Li He-Yan,Yang Qiong,Dong Li,et al.Visual impairment and major eye diseases in stroke: a national cross-sectional study[J].EYE.2023,37(9):1850-1855.doi:10.1038/s41433-022-02238-5.
APA:
Li, He-Yan,Yang, Qiong,Dong, Li,Zhang, Rui-Heng,Zhou, Wen-Da...&Wei, Wen-Bin.(2023).Visual impairment and major eye diseases in stroke: a national cross-sectional study.EYE,37,(9)
MLA:
Li, He-Yan,et al."Visual impairment and major eye diseases in stroke: a national cross-sectional study".EYE 37..9(2023):1850-1855