机构：[1]State Key Laboratory of Experimental Hematology, Haihe Laboratory of Cell Ecosystem, National Clinical Research Center for Blood Diseases, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China.[2]Hongqiao International Institute of Medicine, Shanghai Tongren Hospital, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, China.[3]Center for Stem Cell Medicine, Chinese Academy of Medical Sciences, Tianjin, China.[4]Department of Stem Cell and Regenerative Medicine, Peking Union Medical College, Tianjin, China.
Hematopoietic stem cells, regulated by their microenvironment (or "niche"), sustain the production of mature blood and immune cells. Leukemia cells remodel the microenvironment to enhance their survival, which is accompanied by the loss of support for normal hematopoiesis in hematologic malignancies. Extracellular vesicles (EVs) mediate intercellular communication in physiological and pathological conditions, and deciphering their functions in cell-cell interactions in the ecosystem can highlight potential therapeutic targets. In this Review, we illustrate the utility of EVs derived from various cell types, focusing on the biological molecules they contain and the behavioral alterations they can induce in recipient cells. We also discuss the potential for clinical application in hematologic malignancies, including EV-based therapeutic regimens, drug delivery via EVs, and the use of EVs (or their cargoes) as biomarkers.
基金：
This work was supported by grants from the Ministry of Science and
Technology of China (2020YFE0203000, 2021YFA1100900),
the National Natural Science Foundation of China (81730006,
81922002, 81890990, 81861148029, 81870086, 81825001,
32030030), the Haihe Laboratory of Cell Ecosystem Innovation
Fund (HH22KYZX0016), the Chinese Academy of Medical Sciences (CAMS) Initiative for Innovative Medicine (2021-I2M-1-019,
2021-I2M-1-040), the CAMS Fundamental Research Funds for
Central Research Institutes (3332021093), and Distinguished Young
Scholars of Tianjin (19JCJQJC63400)
第一作者机构：[1]State Key Laboratory of Experimental Hematology, Haihe Laboratory of Cell Ecosystem, National Clinical Research Center for Blood Diseases, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China.
通讯作者：
通讯机构：[1]State Key Laboratory of Experimental Hematology, Haihe Laboratory of Cell Ecosystem, National Clinical Research Center for Blood Diseases, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China.[2]Hongqiao International Institute of Medicine, Shanghai Tongren Hospital, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, China.[3]Center for Stem Cell Medicine, Chinese Academy of Medical Sciences, Tianjin, China.[4]Department of Stem Cell and Regenerative Medicine, Peking Union Medical College, Tianjin, China.[*1]Institute of Hematology and Blood Diseases Hospital, 288 Nanjing Road, Tianjin 300020, China[*2]Shanghai Jiao Tong University School of Medicine, 277 Chongqing South Road, Shanghai 200001, China
推荐引用方式(GB/T 7714)：
Sun Guohuan,Gu Quan,Zheng Junke,et al.Emerging roles of extracellular vesicles in normal and malignant hematopoiesis[J].JOURNAL OF CLINICAL INVESTIGATION.2022,132(18):doi:10.1172/JCI160840.
APA：
Sun Guohuan,Gu Quan,Zheng Junke,Cheng Hui&Cheng Tao.(2022).Emerging roles of extracellular vesicles in normal and malignant hematopoiesis.JOURNAL OF CLINICAL INVESTIGATION,132,(18)
MLA：
Sun Guohuan,et al."Emerging roles of extracellular vesicles in normal and malignant hematopoiesis".JOURNAL OF CLINICAL INVESTIGATION 132..18(2022)
医学