12/15-lipoxygenase (12/15-LOX) is a member of the lipoxygenase family, which can catalyze a variety of polyunsaturated fatty acids (PUFA) to produce different metabolites, such as 12-hydroxyeicosatetraenoic acid (12-HETE), 15-HETE, lipoxin (LX), hepoxilin, resolvin, protectin, and maresins. 12/15-LOX and its metabolites take part in inflammatory responses and mediate related signalling pathways, playing an essential role in various inflammatory diseases. So the definition, catalytic substrates, metabolites of 12/15-lipoxygenase, and their roles in inflammatory responses are reviewed in this article.
基金：
national natural science foundation of China; Beijing Municipal Administration of Hospitals' Mission Plan; Beijing Municipal Administration of Hospitals' Dengfeng plan; [82025010]; [81630023]; [81870698]; [SML20150203]; [DFL20190202]
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2021]版：
大类|3 区生物学
小类|3 区生物工程与应用微生物4 区医学：研究与实验
最新[2023]版：
无
JCR分区：
出版当年[2020]版：
Q2BIOTECHNOLOGY & APPLIED MICROBIOLOGYQ3MEDICINE, RESEARCH & EXPERIMENTAL
最新[2023]版：
Q3BIOTECHNOLOGY & APPLIED MICROBIOLOGYQ3MEDICINE, RESEARCH & EXPERIMENTAL
第一作者机构：[1]Capital Med Univ, Beijing TongRen Hosp, Dept Otolaryngol Head & Neck Surg, Beijing 100730, Peoples R China
通讯作者：
通讯机构：[1]Capital Med Univ, Beijing TongRen Hosp, Dept Otolaryngol Head & Neck Surg, Beijing 100730, Peoples R China[2]Beijing Inst Otolaryngol, Beijing Key Lab Nasal Dis, Beijing 100005, Peoples R China
推荐引用方式(GB/T 7714)：
Tan Ruyu,Yan Bing,Wang Chengshuo,et al.The Role of 12/15-Lipoxygenase and Its Various Metabolites Generated from Multiple Polyunsaturated Fatty Acids as Substrates in Inflammatory Responses[J].BIOMED RESEARCH INTERNATIONAL.2022,2022:doi:10.1155/2022/4589191.
APA：
Tan, Ruyu,Yan, Bing,Wang, Chengshuo&Zhang, Luo.(2022).The Role of 12/15-Lipoxygenase and Its Various Metabolites Generated from Multiple Polyunsaturated Fatty Acids as Substrates in Inflammatory Responses.BIOMED RESEARCH INTERNATIONAL,2022,
MLA：
Tan, Ruyu,et al."The Role of 12/15-Lipoxygenase and Its Various Metabolites Generated from Multiple Polyunsaturated Fatty Acids as Substrates in Inflammatory Responses".BIOMED RESEARCH INTERNATIONAL 2022.(2022)
