Background Correct perioperative antibiotic strategies are crucial to prevent postoperative infections during percutaneous nephrolithotomy (PCNL). We aimed to compare the realistic antibiotic strategies applied in China with current urological guidelines. Methods Between April and May 2020, urologists from China were invited to finish an online cross-sectional survey. The questionnaire was designed according to the current urological guidelines and literatures. Results 3393 completed responses were received. 61.1% (2073/3393) respondents had urological experience of more than 10 years. 72.4% urologists chose multiple-dose antibiotics for patients with both negative urine culture (UC-) and negative urine microscopy (UM-) preoperatively. Respondents in central China (OR = 1.518; 95% CI 1.102-2.092; P = 0.011), east China (OR = 1.528; 95% CI 1.179-1.979; P = 0.001) and northeast China (OR = 1.904; 95% CI 1.298-2.792; P = 0.001) were more likely to prescribe multiple-dose antibiotic for UC-UM- patients. Notably, the respondents who finished PCNL exceeded 100 cases per year were in favor of single-dose administration (OR = 0.674; 95% CI 0.519-0.875; P = 0.003). There are only 8.3% urologists chose single-dose antibiotic for UC-UM+ patients, whereas 65.5% administered antibiotics for 1-3 days. Meanwhile, for UC+ patients, 59.0% of the urologists applied antibiotics shorter than 1 week, and only 26.3% of the urologists carried out routine re-examination of UC. Moreover, postoperative antibiotics were frequently prescribed for 3-6 days (1815; 53.5%). Finally, although 88.2% urologists considered stone culture important for management of postoperative antibiotics as the guideline recommended, only 18.5% performed it routinely. Conclusions The antibiotic strategies are different between current practice in China and the urological guidelines. The dissimilarities suggested that further studies should be conducted to investigate the reasons of the differences and standardize the application of antibiotics.
基金:
National Natural Science Foundation of China [82070719, 81570633]; Natural Science Foundation of Guangdong Province [2020A151501198, 2017A030310148]; Key Project of Department of Education of Guangdong Province [2018KZDXM056]; Science and Technology Program of GuangZhou [202002030042]
第一作者机构:[1]Guangzhou Med Univ, Affiliated Hosp 2, Dept Urol, 250 Changgang Rd, Guangzhou 510260, Guangdong, Peoples R China[2]Guangzhou Med Univ, Guangdong Key Lab Urol, Guangzhou, Peoples R China
共同第一作者:
通讯作者:
通讯机构:[1]Guangzhou Med Univ, Affiliated Hosp 2, Dept Urol, 250 Changgang Rd, Guangzhou 510260, Guangdong, Peoples R China[2]Guangzhou Med Univ, Guangdong Key Lab Urol, Guangzhou, Peoples R China[6]Guangzhou Med Univ, Affiliated Hosp 1, Dept Urol, 1 Kangda Rd, Guangzhou 510230, Guangdong, Peoples R China[8]Shanghai Jiao Tong Univ, Shanghai Gen Hosp, Sch Med, Dept Urol, Shanghai, Peoples R China[9]Shanghai Jiao Tong Univ, Peoples Hosp 1, Shanghai Gen Hosp, Dept Urol, Haining Rd 100, Shanghai 200080, Peoples R China
推荐引用方式(GB/T 7714):
Zhang Shike,Li Gonghui,Qiao Ludong,et al.The antibiotic strategies during percutaneous nephrolithotomy in China revealed the gap between the reality and the urological guidelines[J].BMC UROLOGY.2022,22(1):doi:10.1186/s12894-022-01092-7.
APA:
Zhang, Shike,Li, Gonghui,Qiao, Ludong,Lai, Dehui,He, Zhican...&Wu, Wenqi.(2022).The antibiotic strategies during percutaneous nephrolithotomy in China revealed the gap between the reality and the urological guidelines.BMC UROLOGY,22,(1)
MLA:
Zhang, Shike,et al."The antibiotic strategies during percutaneous nephrolithotomy in China revealed the gap between the reality and the urological guidelines".BMC UROLOGY 22..1(2022)