机构：[1]Department of Ophthalmology and Vision Science, Eye & ENT Hospital, Shanghai Medical School, Fudan University, Shanghai 200031, China[2]Key Laboratory of Myopia, Ministry of Health, Fudan University, Shanghai 200031, China[3]Shanghai Key Laboratory of Visual Impairment and Restoration, Fudan University, Shanghai 200031, China[4]State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai 200032, China[5]Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical首都医科大学附属北京同仁医院首都医科大学附属同仁医院[6]Department of Ophthalmology and Vision Science, Eye & ENT Hospital, Shanghai Medical School, Fudan University, 83 Fenyang Rd, Shanghai 200031, China
Background To investigate the eye movement functions in children with amblyopia and recovered amblyopia by a binocular eye-tracking paradigm. Methods Eye movements of 135 pediatric subjects (age range: 4-14 years), including 45 amblyopic children, 45 recovered amblyopic children and 45 age-similar normal controls, were recorded under binocular viewing with corrected refractive errors (if any). The deviation of gaze positions relative to the target location was recorded as the mean from both eyes. Main outcome measures included fixation deviations (degree) along horizontal and vertical axes in the sustained fixation test (Fix-X, Fix-Y) and visually guided saccade test (Sac-X, Sac-Y), which were compared across the three groups and between each two groups. Results All the four deviations were significantly larger in the amblyopia group compared to the other two groups, indicating increased inaccuracy of sustained and post-saccadic fixations in amblyopia. However, there was no significant difference in deviations between recovered amblyopic children and normal controls. Repeated measures showed similar results overall and within each group. Mild to moderate amblyopes and severe amblyopes did not differ in the four deviations. No significant interaction was found between subject groups and clinical characteristics (age, refractive status, and anisometropia). Conclusion Amblyopic children have poor eye movement functions with increased inaccuracy of sustained and post-saccadic fixations, which appear to be restored in children with recovered amblyopia. Binocular assessment of eye movements provides valuable indicators of functional recovery in amblyopia.
基金：
National Natural Science Foundation of China [81500752, 82271117]; Shanghai Science and Technology Innovation Action Plan [22ZR1410200]
第一作者机构：[1]Department of Ophthalmology and Vision Science, Eye & ENT Hospital, Shanghai Medical School, Fudan University, Shanghai 200031, China[2]Key Laboratory of Myopia, Ministry of Health, Fudan University, Shanghai 200031, China[3]Shanghai Key Laboratory of Visual Impairment and Restoration, Fudan University, Shanghai 200031, China[4]State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai 200032, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Ophthalmology and Vision Science, Eye & ENT Hospital, Shanghai Medical School, Fudan University, Shanghai 200031, China[2]Key Laboratory of Myopia, Ministry of Health, Fudan University, Shanghai 200031, China[3]Shanghai Key Laboratory of Visual Impairment and Restoration, Fudan University, Shanghai 200031, China[4]State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai 200032, China[6]Department of Ophthalmology and Vision Science, Eye & ENT Hospital, Shanghai Medical School, Fudan University, 83 Fenyang Rd, Shanghai 200031, China
推荐引用方式(GB/T 7714)：
Zhou Yulian,Bian Hewei,Yu Xiaobin,et al.Quantitative assessment of eye movements using a binocular paradigm: comparison among amblyopic, recovered amblyopic and normal children[J].BMC OPHTHALMOLOGY.2022,22(1):doi:10.1186/s12886-022-02579-5.
APA：
Zhou, Yulian,Bian, Hewei,Yu, Xiaobin,Wen, Wen&Zhao, Chen.(2022).Quantitative assessment of eye movements using a binocular paradigm: comparison among amblyopic, recovered amblyopic and normal children.BMC OPHTHALMOLOGY,22,(1)
MLA：
Zhou, Yulian,et al."Quantitative assessment of eye movements using a binocular paradigm: comparison among amblyopic, recovered amblyopic and normal children".BMC OPHTHALMOLOGY 22..1(2022)
