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Endotypes of chronic rhinosinusitis based on inflammatory and remodeling factors

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收录情况： ◇ SCIE

作者：
Wang Xiangdong[1,2] * ; Sima Yutong[1,2] * ; Zhao Yan[1,2] * ; Zhang Nan[3] ; Zheng Ming[1] ; Du Kun[1,2] ; Wang Min[1,2] ; Wang Yue[1,2] ; Hao Yun[1,2] ; Li Ying[1,2] ; Liu Manjiao[4] ; Piao Yingshi[5] ; Liu Chengyao[1] ; Tomassen Peter[3] ; Zhang Luo[1,2,6,*1] ; Bachert Claus[3] ;
机构： [1]Department of Otorhinolaryngology Head and Neck Surgery, Department of Allergy, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China [2]Beijing Institute of Otolaryngology, Beijing Laboratory of Allergic Diseases and Beijing Key Laboratory of Nasal Diseases, Key Laboratory of Otolaryngology Head and Neck Surgery, Ministry of Education, Capital Medical University, Beijing 100005, China [3]Upper Airways Research Laboratory, Department of Oto-Rhino-Laryngology, Ghent University Hospital, 9000 Ghent, Belgium [4]Beijing Computing Center, Beijing 100094, China [5]Department of Pathology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China [6]Research Unit of Diagnosis and Treatment of Chronic Nasal Diseases, Chinese Academy of Medical Sciences, Beijing 100005, China
出处：
DOI： 10.1016/j.jaci.2022.10.010
ISSN：

摘要：
Previous studies on the endotyping of chronic rhinosinusitis (CRS) based on inflammatory factors broadened our understanding of the disease. However, the endotype of CRS combined of inflammatory and remodeling features has not yet been clearly elucidated.To identify the endotypes of patients with CRS based on inflammatory and remodeling factors.Forty-eight inflammatory and remodeling factors in the nasal mucosal tissues of 128 CRS patients and 24 control subjects from northern China were analyzed using Luminex, ELISA, and ImmunoCAP. Sixteen factors were used to perform the cluster analysis with partitioning around the medoids method. The characteristics of each cluster were analyzed using correlation analysis and validated by immunofluorescence staining.Patients were classified into five clusters. Clusters 1 and 2 showed non-type 2 signatures with low biomarker concentrations, except for interleukin (IL)-19 and IL-27. Cluster 3 involved a low type 2 endotype with the highest expression of neutrophilic factors, such as granulocyte colony-stimulating factor, IL-8, and myeloperoxidase, and remodeling factors, such as matrix metalloproteinases and fibronectin. Cluster 4 exhibited moderate type 2 inflammation. Cluster 5 exhibited high type 2 inflammation, which was associated with relatively higher levels of neutrophilic and remodeling factors. The proportion of CRS with nasal polyps, asthma, allergies, anosmia, aspirin sensitivity, and the recurrence of CRS increased from Clusters 1 to 5.Diverse inflammatory mechanisms result in distinct CRS endotypes and remodeling profiles. The explicit differentiation and accurate description of these endotypes will guide targeted treatment decisions.Copyright © 2022. Published by Elsevier Inc.

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出版当年[2022]版：
大类 | 1 区 医学
小类 | 1 区 过敏 1 区 免疫学
最新[2025]版：
大类 | 1 区 医学
小类 | 1 区 过敏 1 区 免疫学
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出版当年[2021]版：
Q1 ALLERGY Q1 IMMUNOLOGY
最新[2023]版：
Q1 ALLERGY Q1 IMMUNOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2021版] 出版当年五年平均 出版前一年[2020版] 出版后一年[2022版]

第一作者：
第一作者机构： [1]Department of Otorhinolaryngology Head and Neck Surgery, Department of Allergy, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China [2]Beijing Institute of Otolaryngology, Beijing Laboratory of Allergic Diseases and Beijing Key Laboratory of Nasal Diseases, Key Laboratory of Otolaryngology Head and Neck Surgery, Ministry of Education, Capital Medical University, Beijing 100005, China
共同第一作者：
通讯作者：
通讯机构： [1]Department of Otorhinolaryngology Head and Neck Surgery, Department of Allergy, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China [2]Beijing Institute of Otolaryngology, Beijing Laboratory of Allergic Diseases and Beijing Key Laboratory of Nasal Diseases, Key Laboratory of Otolaryngology Head and Neck Surgery, Ministry of Education, Capital Medical University, Beijing 100005, China [6]Research Unit of Diagnosis and Treatment of Chronic Nasal Diseases, Chinese Academy of Medical Sciences, Beijing 100005, China [*1]Beijing Institute of Otolaryngology,No. 17, Hougou Hutong, Dong Cheng District, Beijing 100005, China
推荐引用方式(GB/T 7714)：
Wang Xiangdong,Sima Yutong,Zhao Yan,et al.Endotypes of chronic rhinosinusitis based on inflammatory and remodeling factors[J].JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY.2023,151(2):458-468.doi:10.1016/j.jaci.2022.10.010.
APA：
Wang Xiangdong,Sima Yutong,Zhao Yan,Zhang Nan,Zheng Ming...&Bachert Claus.(2023).Endotypes of chronic rhinosinusitis based on inflammatory and remodeling factors.JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY,151,(2)
MLA：
Wang Xiangdong,et al."Endotypes of chronic rhinosinusitis based on inflammatory and remodeling factors".JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 151..2(2023):458-468

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