机构：[1]Department of Clinical Laboratory, Beijing Tiantan Hospital Affiliated to Capital Medical University, NO. 119 South Fourth Ring West Road,首都医科大学附属天坛医院[2]Department of Oncology, Beijing Tongren Hospital Affiliated to Capital Medical University, Beijing 100730, China首都医科大学附属北京同仁医院临床科室肿瘤中心[3]Department of Pathology, Beijing Tongren Hospital Affiliated to Capital Medical University, Beijing 100730, China医技科室病理科首都医科大学附属北京同仁医院首都医科大学附属同仁医院[4]Department of Clinical Laboratory, Beijing Tiantan Hospital Affiliated to Capital Medical University, Beijing100050, China首都医科大学附属天坛医院
Some members of the tripartite motif-containing protein family have been reported as important regulators of carcinogenesis. In the present study, it was investigated whether tripartite motif-containing protein 44 (TRIM44) acts as a pro-oncogene through their over-expression in laryngeal squamous cell carcinoma. Its results showed that TRIM44 was up-regulated in tumor tissues and cell lines of laryngeal squamous cell carcinoma. In vitro, knockdown of TRIM44 significantly inhibited cell growth of laryngeal squamous cell carcinoma. Furthermore, TRIM44 knockdown inhibited tumor growth in nude mice in vivo, further suggesting the oncogenic activity of TRIM44 in laryngeal squamous cell carcinoma. Also, TRIM44 positively correlated with TLR4 at the mRNA and protein levels, and Si-RNA-NF-κB restrained laryngeal squamous cell carcinoma from proliferating. All indicated that TRIM44 might play a key role in tumor invasion through their over-expression and inhibition of TRIM44 is an effective strategy for the treatment of laryngeal squamous cell carcinoma.
基金：
Beijing Health System
High-level Talent Program (Grant 2022-3-045).
第一作者机构：[1]Department of Clinical Laboratory, Beijing Tiantan Hospital Affiliated to Capital Medical University, NO. 119 South Fourth Ring West Road,
通讯作者：
推荐引用方式(GB/T 7714)：
Bai Jing,Liu Xiangyi,Zhang Shurong,et al.Expression of TRIM44 and its correlation with TLR4 in laryngeal squamous cell carcinoma[J].CELLULAR AND MOLECULAR BIOLOGY.2022,68(6):56-61.doi:10.14715/cmb/2022.68.6.9.
APA：
Bai Jing,Liu Xiangyi,Zhang Shurong,Dang Shoutao,Zhang Yong&Zhang Guojun.(2022).Expression of TRIM44 and its correlation with TLR4 in laryngeal squamous cell carcinoma.CELLULAR AND MOLECULAR BIOLOGY,68,(6)
MLA：
Bai Jing,et al."Expression of TRIM44 and its correlation with TLR4 in laryngeal squamous cell carcinoma".CELLULAR AND MOLECULAR BIOLOGY 68..6(2022):56-61
