详情页 - 首都医科大学附属北京同仁医院知识库

当前位置：首页 > 详情页

Integrative analysis deciphers the heterogeneity of cancer-associated fibroblast and implications on clinical outcomes in ovarian cancers

7| 认领 | 导出 | 链接全文 |

文献详情

资源类型：

WOS体系：

Pubmed体系：

收录情况： ◇ SCIE

作者：

机构： [1]Beijing Tongren Hospital, Capital Medical University and Beijing Institute of Otolaryngology, Beijing, China. [2]Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai, China. [3]Beijing Cloudna Technology Co., Ltd., Beijing, China. [4]Institute of Chinese Medical Sciences, University of Macau, Macau, China. [5]Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China. [6]University of Maryland School of Medicine, Baltimore, MD, USA.

出处：

DOI：

ISSN：

摘要：

Accumulating evidence has recognized that cancer-associated fibroblasts (CAFs) are major players in the desmoplastic stroma of ovarian cancer, modulating tumor progression and therapeutic response. However, it is unclear regarding the signatures of CAFs could be utilized to predict the clinical outcomes of ovarian cancer patients. To fill in this gap, we explored the intratumoral compartment of ovarian cancer by analyzing the single-cell RNA-sequencing (scRNA-seq) datasets of ovarian carcinoma samples, and identified two distinct CAFs (tumor-promoting CAF_c1 subtype and myofibroblasts-like CAF_c2 subtype). The clinical significance of CAF subtypes was further validated in The Cancer Genomics Atlas (TCGA) database and other independent immunotherapy response datasets, and the results revealed that the patients with a higher expression of CAF_c1 signatures had a worse prognosis and showed a tendency of resistance to immunotherapy. This work uncovered the signatures of the CAF_c1 subtype that could serve as a novel prognostic indicator and predictive marker for immunotherapy.© 2022 The Author(s).

基金：

语种：

被引次数：

WOS：

PubmedID：

中科院(CAS)分区：

出版当年[2021]版：

大类 | 3 区生物学

小类 | 3 区生化与分子生物学

最新[2025]版：

大类 | 3 区生物学

小类 | 3 区生化与分子生物学

JCR分区：

出版当年[2020]版：

Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

最新[2023]版：

Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

影响因子： 4.5 最新[2023版] 5.1 最新五年平均 7.271 出版当年[2020版] 7.409 出版当年五年平均 6.018 出版前一年[2019版] 6.155 出版后一年[2021版]

第一作者：

第一作者机构： [1]Beijing Tongren Hospital, Capital Medical University and Beijing Institute of Otolaryngology, Beijing, China.

共同第一作者：

通讯作者：

通讯机构： [5]Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China. [6]University of Maryland School of Medicine, Baltimore, MD, USA. [*1]: Beijing Pediatric Research Institute, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, 56 South Lishi Road, Beijing 100045, China.

推荐引用方式(GB/T 7714)：

APA：

MLA：