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Fabrication of biphasic cartilage-bone integrated scaffolds based on tissue-specific photo-crosslinkable acellular matrix hydrogels

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收录情况： ◇ SCIE

作者：
Hua Yujie[1,4,5] * ; Huo Yingying[1,4] * ; Bai Baoshuai[6] * ; Hao Junxiang[3,4] * ; Hu Guanhuai[5] ; Ci Zheng[3,4] ; Wu Xiaodi[3,4] ; Yu Mengyuan[5] ; Wang Xin[7] ; Chen Hong[7] ; Ren Wenjie[5] ; Zhang Yixin[1] ; Wang Xiaoyun[2] ; Zhou Guangdong[1,3,4,5,*1] ;
机构： [1]Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Tissue Engineering, Shanghai, PR China [2]Department of Plastic Surgery, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Tissue Engineering, Shanghai, PR China c Research Institute of Plastic Surgery, Weifang Medical University, Weifang, Shandong, PR China [3]National Tissue Engineering Center of China, Shanghai, PR China [4]Institute of Regenerative Medicine and Orthopedics, Institutes of Health Central Plain, Xinxiang Medical University, Xinxiang, Henan, PR China [5]Department of Orthopaedics, Qilu Hospital of Shangdong University Centre for Orthopaedics, Advanced Medical Research Institute, Shangdong University, Shangdong, PR China [6]Department of Hand Surgery, Ningbo Sixth Hospital, Zhejiang, PR China
出处：
DOI： 10.1016/j.mtbio.2022.100489
ISSN：

摘要：
The fabrication of biphasic cartilage-bone integrated scaffolds is an attractive alternative for osteochondral repair but has proven to be extremely challenging. Existing three-dimensional (3D) scaffolds are insufficient to accurately biomimic the biphasic cartilage-bone integrated microenvironment. Currently, photo-crosslinkable hydrogels based on tissue-specific decellularized extracellular matrix (dECM) have been considered as an important technique to fabricate biomimetic scaffolds, but so far there has been no breakthrough in the photo-crosslinkable hydrogel scaffolds with biphasic cartilage-bone biomimetic microenvironment. Here, we report a novel strategy for the preparation of biomimetic cartilage-bone integrated scaffolds based on photo-crosslinkable cartilage/bone-derived dECM hydrogels, which are able to reconstruct biphasic cartilage-bone biomimetic microenvironment. The biphasic cartilage-bone integrated scaffolds provided a 3D microenvironment for osteochondral regeneration. The cartilage biomimetic scaffolds, consisting of cartilage-derived dECM hydrogels, efficiently regulated chondrogenesis of bone marrow mesenchymal stem cells (BMSCs). The bone biomimetic scaffolds, composed of cartilage/bone-derived dECM hydrogels, first regulated chondrogenesis of BMSCs, followed by endochondral ossification over time. Taken together, the biphasic cartilage-bone integrated tissue could be successfully reconstructed by subcutaneous culture based on cartilage-bone bilayered structural design. Furthermore, the biphasic cartilage-bone biomimetic scaffolds (cell-free) achieved satisfactory cartilage-bone integrated regeneration in the osteochondral defects of rabbits' knee joints.© 2022 The Authors. Published by Elsevier Ltd.

基金：
This research was financially supported by the National Key Research and Development Program of China (2017YFC1103900, 2018YFC1105800), the National Natural Science Foundation of China (81871502, 81701843, and 81671837), the Shanghai Excellent Technical Leader (18XD1421500), the Program of Shanghai Academic/ Technology Research Leader (19XD1431100), the Shanghai Collaborative Innovation Program on Regenerative Medicine and Stem Cell Research (2019CXJQ01), the Key Research and Development Program of Henan province (No. 221111310100), Major Science and Technology Projects of Xinxiang City (No. 21ZD006), the Clinical Research Plan of SHDC (No. SHDC2020CR2045B), and Zhejiang Medical and Health Science and Technology Project (2019KY624). The authors also thank Prof. Linyong Zhu's group (Shanghai Jiao Tong University) for the help with materials' characterization.
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外文
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中科院(CAS)分区：
出版当年[2021]版：
大类 | 3 区 材料科学
小类 | 3 区 工程：生物医学 3 区 材料科学：生物材料
最新[2025]版：
大类 | 1 区 医学
小类 | 1 区 材料科学：生物材料 2 区 工程：生物医学
JCR分区：
出版当年[2020]版：
Q1 MATERIALS SCIENCE, BIOMATERIALS Q1 ENGINEERING, BIOMEDICAL
最新[2023]版：
Q1 ENGINEERING, BIOMEDICAL Q1 MATERIALS SCIENCE, BIOMATERIALS

影响因子： 最新[2023版] 最新五年平均 出版当年[2020版] 出版当年五年平均 出版前一年[2019版] 出版后一年[2021版]

第一作者：
第一作者机构： [1]Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Tissue Engineering, Shanghai, PR China [4]Institute of Regenerative Medicine and Orthopedics, Institutes of Health Central Plain, Xinxiang Medical University, Xinxiang, Henan, PR China [5]Department of Orthopaedics, Qilu Hospital of Shangdong University Centre for Orthopaedics, Advanced Medical Research Institute, Shangdong University, Shangdong, PR China
共同第一作者：
通讯作者：
通讯机构： [1]Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Tissue Engineering, Shanghai, PR China [3]National Tissue Engineering Center of China, Shanghai, PR China [4]Institute of Regenerative Medicine and Orthopedics, Institutes of Health Central Plain, Xinxiang Medical University, Xinxiang, Henan, PR China [5]Department of Orthopaedics, Qilu Hospital of Shangdong University Centre for Orthopaedics, Advanced Medical Research Institute, Shangdong University, Shangdong, PR China [*1]Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Tissue Engineering, Shanghai, PR China
推荐引用方式(GB/T 7714)：
Hua Yujie,Huo Yingying,Bai Baoshuai,et al.Fabrication of biphasic cartilage-bone integrated scaffolds based on tissue-specific photo-crosslinkable acellular matrix hydrogels[J].MATERIALS TODAY BIO.2022,17:doi:10.1016/j.mtbio.2022.100489.
APA：
Hua Yujie,Huo Yingying,Bai Baoshuai,Hao Junxiang,Hu Guanhuai...&Zhou Guangdong.(2022).Fabrication of biphasic cartilage-bone integrated scaffolds based on tissue-specific photo-crosslinkable acellular matrix hydrogels.MATERIALS TODAY BIO,17,
MLA：
Hua Yujie,et al."Fabrication of biphasic cartilage-bone integrated scaffolds based on tissue-specific photo-crosslinkable acellular matrix hydrogels".MATERIALS TODAY BIO 17.(2022)

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