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Retinal toxicity of long term overdose of sildenafil citrate: A case report

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机构： [1]Department of Ophthalmology, Peking University People's Hospital, Beijing, China. [2]Eye Diseases and Optometry Institute, Beijing, China. [3]Beijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroid Diseases, Beijing, China. [4]College of Optometry, Peking University Health Science Center, Beijing, China.

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关键词： Sildenafil citrate Retinal photoreceptor cells PDE-6

摘要：

To report a case of eye structure changes in a patient with long-term overdose of sildenafil citrate.A 28-year-old male presented to our outpatient clinic with flare sensation in both eyes for 1 year after taking sildenafil citrate at a dose of 200 mg daily for two years. mERG and OCT examination revealed persistent damage of retinal photoreceptor cells. The symptoms did not disappear after 3 months off the medication.Long term excessive use of overdose sildenafil citrate can cause serious damage to retinal photoreceptor cells. The retinal side effects of sildenafil citrate still need to be further investigated, and the administration of systemic overdose also needs to be considered by all physicians, not just ophthalmologists.© 2022 Published by Elsevier Inc.

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第一作者机构： [1]Department of Ophthalmology, Peking University People's Hospital, Beijing, China. [2]Eye Diseases and Optometry Institute, Beijing, China. [3]Beijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroid Diseases, Beijing, China. [4]College of Optometry, Peking University Health Science Center, Beijing, China.

通讯机构： [*1]Department of Ophthalmology, Peking University People’s Hospital, Xizhimen South Street 11, Xicheng District, 100044, Beijing, China

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Retinal toxicity of long term overdose of sildenafil citrate: A case report

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