机构：[1]Department of Ophthalmology, Bascom Palmer Eye Institute, 22130University of Miami Miller School of Medicine, Miami, Florida, USA.[2]Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China.首都医科大学附属北京同仁医院首都医科大学附属同仁医院
To report the outcomes of slow-coagulation continuous-wave transscleral cyclophotocoagulation (CW-TSCPC) in post-keratoplasty glaucoma refractory to medical therapy.Medical records of 47 patients (mean age of 70.7 ± 15.7 years and follow-up of 13.9 ± 7.1 months) were retrospectively enrolled. All patients had the diagnosis of secondary glaucoma after penetrating keratoplasty (PKP; n = 28) or Descemet's stripping automated endothelial keratoplasty (DSAEK; n = 19) with no previous history of incisional glaucoma or TSCPC surgeries. Study participants underwent slow-coagulation CW-TSCPC (1250-milliwatt power and 4-second duration).A statically significant reduction of IOP from 31.8 ± 8.0 mmHg preoperatively to 16.9 ± 9.0 mmHg postoperatively was noted (p < 0.001). Similarly, the number of glaucoma medications decreased from 4.0 ± 1.0 to 2.7 ± 1.4 (p < 0.001). The overall success rates at 12 and 24 months were 68.1% and 66.0%, respectively, with no difference in success rates between post-PKP and post-DSAEK subgroups (p = 0.836). No significant changes in VA or central corneal thickness (CCT) were observed (p = 0.345 and 0.311, respectively). One (3.3%) patient had a graft rejection. The majority of the complications noted during this study were mild and transient.Our study suggests that slow-coagulation TSCPC may be a safe and efficient surgical glaucoma treatment modality in patients with medically uncontrolled post-keratoplasty glaucoma.
基金：
The author(s) disclosed receipt of the following financial support
for the research, authorship, and/or publication of this article: This
work was supported by the Camiener Foundation Glaucoma
Research Fund, Research to Prevent Blindness Unrestricted
Grant, Gutierrez Family Research Fund, NIH Center Core
Grant, Walter G. Ross Foundation, (grant number P30EY014801)
第一作者机构：[1]Department of Ophthalmology, Bascom Palmer Eye Institute, 22130University of Miami Miller School of Medicine, Miami, Florida, USA.
通讯作者：
通讯机构：[1]Department of Ophthalmology, Bascom Palmer Eye Institute, 22130University of Miami Miller School of Medicine, Miami, Florida, USA.[*1]Walter G. Ross Distinguished Chair in Ophthalmology, Associate Professor of Ophthalmology, Cell Biology, Electrical and Computer Engineering, and Neuroscience Graduate Program, Program Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, 900 NW 17th Street, Miami, FL 33136, USA.
推荐引用方式(GB/T 7714)：
Khodeiry Mohamed M,Liu Xiangxiang,Sayed Mohamed S,et al.Outcomes of primary surgical treatment of medically recalcitrant post-keratoplasty glaucoma with transscleral cyclophotocoagulation[J].EUROPEAN JOURNAL OF OPHTHALMOLOGY.2023,33(4):1658-1665.doi:10.1177/11206721221149514.
APA：
Khodeiry Mohamed M,Liu Xiangxiang,Sayed Mohamed S&Lee Richard K.(2023).Outcomes of primary surgical treatment of medically recalcitrant post-keratoplasty glaucoma with transscleral cyclophotocoagulation.EUROPEAN JOURNAL OF OPHTHALMOLOGY,33,(4)
MLA：
Khodeiry Mohamed M,et al."Outcomes of primary surgical treatment of medically recalcitrant post-keratoplasty glaucoma with transscleral cyclophotocoagulation".EUROPEAN JOURNAL OF OPHTHALMOLOGY 33..4(2023):1658-1665
