个人科研网厅 | | 帮助
高级检索
当前位置： 首页 > 详情页

Reconstruction of the tumor spatial microenvironment along the malignant-boundary-nonmalignant axis

| 认领 | 导出 | |

文献详情

资源类型：
WOS体系：
Pubmed体系：

收录情况： ◇ SCIE ◇ 自然指数

作者：
Xun Zhenzhen[1,2] * ; Ding Xinyu[1,2] ; Zhang Yao[3] ; Zhang Benyan[4] ; Lai Shujing[2] ; Zou Duowu[3] ; Zheng Junke[5] ; Chen Guoqiang[6] ; Su Bing[1,2] ; Han Leng[7] ; Ye Youqiong[1,2] ;
机构： [1]Center for Immune-Related Diseases at Shanghai Institute of Immunology, Department of Gastroenterology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. [2]Shanghai Institute of Immunology, State Key Laboratory of Oncogenes and Related Genes, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China. [3]Department of Gastroenterology, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China. [4]Department of Pathology, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China. [5]Hongqiao International Institute of Medicine, Shanghai Tongren Hospital, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Faculty of Basic Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China. [6]State Key Laboratory of Oncogenes and Related Genes, and Research Unit of Stress and Cancer, Chinese Academy of Medical Sciences, Shanghai Cancer Institute, Renji hospital, Shanghai Jiao Tong University School of Medicine (SJTU-SM), Shanghai, 200127, China. [7]Center for Epigenetics and Disease Prevention, Institute of Biosciences and Technology, Texas A&M University, Houston, TX, 77030, USA
出处：
DOI： 10.1038/s41467-023-36560-7
ISSN：

摘要：
Although advances in spatial transcriptomics (ST) enlarge to unveil spatial landscape of tissues, it remains challenging to delineate pathology-relevant and cellular localizations, and interactions exclusive to a spatial niche (e.g., tumor boundary). Here, we develop Cottrazm, integrating ST with hematoxylin and eosin histological image, and single-cell transcriptomics to delineate the tumor boundary connecting malignant and non-malignant cell spots in tumor tissues, deconvolute cell-type composition at spatial location, and reconstruct cell type-specific gene expression profiles at sub-spot level. We validate the performance of Cottrazm along the malignant-boundary-nonmalignant spatial axis. We identify specific macrophage and fibroblast subtypes localized around tumor boundary that interacted with tumor cells to generate a structural boundary, which limits T cell infiltration and promotes immune exclusion in tumor microenvironment. In this work, Cottrazm provides an integrated tool framework to dissect the tumor spatial microenvironment and facilitates the discovery of functional biological insights, thereby identifying therapeutic targets in oncologic ST datasets.© 2023. The Author(s).

基金：
National key research and development program (2022YFC2504700 to Y.Y.), National Natural Science Foundation of China (81971487 and 82203189 to Y.Y., 32100730 to S.L.), Shanghai Science and Technology Commission (20JC1410100 to Q.C.), Natural Science Foundation of Shanghai (20ZR1472900 to Y.Y.), Shanghai Jiao Tong University 2030 Initiative (WH510363001-4 to Y.Y.), and National Postdoctoral Program for Innovative Talent (BX2021188 to S.L.).
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类 | 1 区 综合性期刊
小类 | 1 区 综合性期刊
最新[2025]版：
大类 | 1 区 综合性期刊
小类 | 1 区 综合性期刊
JCR分区：
出版当年[2021]版：
Q1 MULTIDISCIPLINARY SCIENCES
最新[2023]版：
Q1 MULTIDISCIPLINARY SCIENCES

影响因子： 最新[2023版] 最新五年平均 出版当年[2021版] 出版当年五年平均 出版前一年[2020版] 出版后一年[2022版]

第一作者：
第一作者机构： [1]Center for Immune-Related Diseases at Shanghai Institute of Immunology, Department of Gastroenterology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. [2]Shanghai Institute of Immunology, State Key Laboratory of Oncogenes and Related Genes, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
通讯作者：
通讯机构： [1]Center for Immune-Related Diseases at Shanghai Institute of Immunology, Department of Gastroenterology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. [2]Shanghai Institute of Immunology, State Key Laboratory of Oncogenes and Related Genes, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
推荐引用方式(GB/T 7714)：
Xun Zhenzhen,Ding Xinyu,Zhang Yao,et al.Reconstruction of the tumor spatial microenvironment along the malignant-boundary-nonmalignant axis[J].NATURE COMMUNICATIONS.2023,14(1):933.doi:10.1038/s41467-023-36560-7.
APA：
Xun Zhenzhen,Ding Xinyu,Zhang Yao,Zhang Benyan,Lai Shujing...&Ye Youqiong.(2023).Reconstruction of the tumor spatial microenvironment along the malignant-boundary-nonmalignant axis.NATURE COMMUNICATIONS,14,(1)
MLA：
Xun Zhenzhen,et al."Reconstruction of the tumor spatial microenvironment along the malignant-boundary-nonmalignant axis".NATURE COMMUNICATIONS 14..1(2023):933

资源点击量：23594 今日访问量：3 总访问量：1285 更新日期：2025-04-01 建议使用谷歌、火狐浏览器 常见问题

版权所有©2020 首都医科大学附属北京同仁医院 技术支持：重庆聚合科技有限公司 地址：北京市东城区东交民巷1号(100730)