详情页 - 首都医科大学附属北京同仁医院知识库

当前位置：首页 > 详情页

High expression of SDC1 in stromal cells is associated with good prognosis in colorectal cancer

3| 认领 | 导出 | 链接全文 |

文献详情

资源类型：

WOS体系：

Pubmed体系：

收录情况： ◇ SCIE

作者：

机构： [1]Department of Pathology, Affiliated Hospital of Jining Medical University, Jining Medical University, Jining, Shandong. [2]Department of Pathology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.

出处：

DOI：

ISSN：

关键词： colorectal cancer prognosis SDC1 stromal cells

摘要：

We have previously reported that patients with high Syndecan 1 (SDC1) expression in colorectal cancer (CRC) cells have a favorable prognosis, and we also found that stromal cells showed upregulation of SDC1, but the clinical significance is unclear. The expression of SDC1 in the stroma cells was assessed by immunohistochemistry using a tissue microarray comprising representative cores from 513 CRC patients. The correlation between the expression of SDC1 in the stroma cells and the clinicopathological features of patients was analyzed. The data showed that the expression of SDC1 in the stroma cells was correlated with the degree of differentiation (P = 0.012) and tumor location (up or down) (P = 0.005). Also, CRCs patients with high expression of SDC1 in the stromal cells have a good prognosis (P = 0.0369). Accumulating evidence indicates that SDC1, whether in tumor cells or stromal cells, plays a tumor-suppressor role in CRCs.Copyright © 2022 The Author(s). Published by Wolters Kluwer Health, Inc.

基金：

语种：

被引次数：

WOS：

PubmedID：

中科院(CAS)分区：

出版当年[2022]版：

大类 | 4 区医学

小类 | 4 区药学 4 区肿瘤学

最新[2025]版：

大类 | 4 区医学

小类 | 4 区肿瘤学 4 区药学

JCR分区：

出版当年[2021]版：

Q4 ONCOLOGY Q4 PHARMACOLOGY & PHARMACY

最新[2023]版：

Q3 ONCOLOGY Q3 PHARMACOLOGY & PHARMACY

影响因子： 1.8 最新[2023版] 1.9 最新五年平均 2.389 出版当年[2021版] 2.384 出版当年五年平均 2.248 出版前一年[2020版] 2.3 出版后一年[2022版]

第一作者：

第一作者机构： [1]Department of Pathology, Affiliated Hospital of Jining Medical University, Jining Medical University, Jining, Shandong.

共同第一作者：

通讯作者：

通讯机构： [1]Department of Pathology, Affiliated Hospital of Jining Medical University, Jining Medical University, Jining, Shandong. [*1]Department of Pathology, Affiliated Hospital of Jining Medical University, Jining Medical University, Jining, Shandong 272029, China

推荐引用方式(GB/T 7714)：

APA：

MLA：

相关文献

[1]IL-36 s in the colorectal cancer: is interleukin 36 good or bad for the development of colorectal cancer? [2]Construction and validation of a metabolic-associated lncRNA risk index for predicting colorectal cancer prognosis [3]CRYAB predicts clinical prognosis and is associated with immunocyte infiltration in colorectal cancer [4]结直肠癌中rhogdi2的表达与肿瘤侵袭、转移及预后的关系 [5]Interleukin-38 in colorectal cancer: a potential role in precision medicine [6]Correlation between miR-21 and miR-145 and the incidence and prognosis of colorectal cancer [7]Development and Clinical Validation of a Novel 4-Gene Prognostic Signature Predicting Survival in Colorectal Cancer [8]Comprehensive analysis of ATP6V1s family member, ATP6V1C2, with prognostic and drug development values in colorectal cancer [9]Population-based screening for colorectal cancer in Wuhan, China [10]腹腔镜结直肠癌根治术治疗不同分期结直肠癌的效果及安全性分析