There is growing evidence that long non-coding RNAs (lncRNAs) are significant contributors to the epigenetic mechanisms implicated in the emergence, progression and metastasis of the colorectal cancer (CRC), but many remain underexplored. A novel lncRNA LOC105369504, was identified to be a potential functional lncRNA by microarray analysis. In CRC, the expression of LOC105369504 was markedly decreased and resulted in distinct variations in proliferation, invasion, migration and epithelial-mesenchymal transition (EMT) in vivo and in vitro. This study showed that LOC105369504 bound to the protein of paraspeckles compound 1 (PSPC1) directly and regulated its stability using the ubiquitin-proteasome pathway in CRC cells. The suppression of CRC by LOC105369504 could be reversed through PSPC1 overexpression.This study showed that in CRC, LOC105369504 was under-regulated and as a novel lncRNA, LOC105369504 exerted tumor suppressive activity to suppress the proliferation together with metastasis in CRC cells through the regulation of PSPC1. These results offer new perspectives on the lncRNA effect on the progression of CRC.
基金：
This work was supported financially through the Central Guidance Local Science and
Technology Development of Hubei Province (Grant No. 2019ZYYD067) and the
National Natural Science Foundation of China (Grant No. 82100559).
第一作者机构：[1]WuHan Univ, Tongren Hosp, WuHan Hosp 3, Dept Gastroenterol, Wuhan 430060, Peoples R China
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推荐引用方式(GB/T 7714)：
Zhan Ting,Cheng Xueting,Zhu Qingxi,et al.LncRNA LOC105369504 inhibits tumor proliferation and metastasis in colorectal cancer by regulating PSPC1[J].CELL DEATH DISCOVERY.2023,9(1):doi:10.1038/s41420-023-01384-3.
APA：
Zhan, Ting,Cheng, Xueting,Zhu, Qingxi,Han, Zheng,Zhu, Kejing...&Huang, Xiaodong.(2023).LncRNA LOC105369504 inhibits tumor proliferation and metastasis in colorectal cancer by regulating PSPC1.CELL DEATH DISCOVERY,9,(1)
MLA：
Zhan, Ting,et al."LncRNA LOC105369504 inhibits tumor proliferation and metastasis in colorectal cancer by regulating PSPC1".CELL DEATH DISCOVERY 9..1(2023)
