机构：[1]Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China首都医科大学附属天坛医院[2]China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China首都医科大学附属天坛医院[3]Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China首都医科大学附属北京同仁医院首都医科大学附属同仁医院[4]Department of Anesthesiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking UnionMedical College, Beijing, China[5]Beijing Institute for Brain Disorders, Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing, China
BackgroundThis study aims to explore the relationship between psychiatric disorders and the risk of epilepsy using Mendelian randomization (MR) analysis. MethodsWe collected summary statistics of seven psychiatric traits from recent largest genome-wide association study (GWAS), including major depressive disorder (MDD), anxiety disorder, autism spectrum disorder (ASD), bipolar disorder (BIP), attention deficit hyperactivity disorder (ADHD), schizophrenia (SCZ), and insomnia. Then, MR analysis estimates were performed based on International League Against Epilepsy (ILAE) consortium data (n(case) = 15,212 and n(control) = 29,677), the results of which were subsequently validated in FinnGen consortium (n(case) = 6260 and n(control) = 176,107). Finally, a meta-analysis was conducted based on the ILAE and FinnGen data. ResultsWe found significant causal effects of MDD and ADHD on epilepsy in the meta-analysis of the ILAE and FinnGen, with corresponding odds ratios (OR) of 1.20 (95% CI 1.08-1.34, p = .001) and 1.08 (95% CI 1.01-1.16, p = .020) by the inverse-variance weighted (IVW) method respectively. MDD increases the risk of focal epilepsy while ADHD has a risk effect on generalized epilepsy. No reliable evidence regarding causal effects of other psychiatric traits on epilepsy was identified. ConclusionsThis study suggests that major depressive disorder and attention deficit hyperactivity disorder may causally increase the risk of epilepsy.
基金：
National Key Technologies R&D Program of China [2022YFC2503800]; Beijing Municipal Natural Science Foundation [Z200024]
第一作者机构：[1]Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China[2]China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
通讯作者：
通讯机构：[1]Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China[2]China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China[5]Beijing Institute for Brain Disorders, Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing, China[*1]Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China.
推荐引用方式(GB/T 7714)：
Li Gongfei,Wang Minghui,Zheng Meiqi,et al.Causal effect of psychiatric disorders on epilepsy: A two-sample Mendelian randomization study[J].BRAIN AND BEHAVIOR.2023,13(4):doi:10.1002/brb3.2939.
APA：
Li, Gongfei,Wang, Minghui,Zheng, Meiqi,Liu, Xiao,Yu, Tingting...&Wang, Qun.(2023).Causal effect of psychiatric disorders on epilepsy: A two-sample Mendelian randomization study.BRAIN AND BEHAVIOR,13,(4)
MLA：
Li, Gongfei,et al."Causal effect of psychiatric disorders on epilepsy: A two-sample Mendelian randomization study".BRAIN AND BEHAVIOR 13..4(2023)
