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Cu2-x Se nanoparticles suppress cell proliferation and migration in hepatocellular carcinoma by impairing mitochondrial respiration

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机构: [1]Department of Pharmacy, Army Medical University, 83 Xinqiao Road, Shapingba, Chongqing, 400037, China, Chongqing, 400038, CHINA. [2]Department of Pharmacy, Army Medical University, 83 Xinqiao Road, Chongqing 400037, China, Chongqing, 400038, CHINA. [3]Beijing Tongren Hospital, No. 1 Dongjiaominxiang Road, Dongcheng District, Beijing 100730, China, Beijing, 100730, CHINA.
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Cu2-xSe nanoparticles (Cu2-xSe NPs) as a new therapeutic drug platform is widely used in disease treatment due to their strong near-infrared (NIR) optical absorption. In recent years, with their continuo expansion of applications in different fields, their own biological effects have received increasing attention. However, little is known about the effect of Cu2-xSe NPs on cancer cell. In this research, we found that Cu2-xSe NPs inhibited proliferation of HepG2 and SMMC-7721 cells and they mainly induced cell cycle arrest at the G2/M phase. Moreover, Cu2-xSe NPs inhibited HepG2 and SMMC-7721 cell migration and lamellopodia formation. Further studies indicated that Cu2-xSe NPs impaired mitochondrial respiration by inhibiting electron transport chain (ETC) complex activity, thus reducing ATP levels. The insufficient energy supply subsequently impaired actin cytoskeleton assembly, ultimately inhibiting HepG2 and SMMC-7721 cell proliferation and migration.These findings suggest that Cu2-xSe NPs may has potentially antitumor activity, which might provide new insights of nanoparticles into specific cancer treatment.&#xD.© 2023 IOP Publishing Ltd.

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出版当年[2022]版:
大类 | 3 区 工程技术
小类 | 4 区 材料科学:生物材料 4 区 工程:生物医学
最新[2023]版:
大类 | 3 区 医学
小类 | 4 区 工程:生物医学 4 区 材料科学:生物材料
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出版当年[2021]版:
Q2 ENGINEERING, BIOMEDICAL Q3 MATERIALS SCIENCE, BIOMATERIALS
最新[2023]版:
Q2 ENGINEERING, BIOMEDICAL Q3 MATERIALS SCIENCE, BIOMATERIALS

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第一作者机构: [1]Department of Pharmacy, Army Medical University, 83 Xinqiao Road, Shapingba, Chongqing, 400037, China, Chongqing, 400038, CHINA.
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