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OCT Optic Nerve Head Morphology in Myopia II: Peri-Neural Canal Scleral Bowing and Choroidal Thickness in High Myopia An American Ophthalmological Society Thesis

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收录情况： ◇ SCIE

作者：
Burgoyne Claude F[1,2,*1] * ; Wang Ya Xing[3] ; Jeoung Jin Wook[4] ; Hong Seungwoo[5] ; Gardiner Stuart[2] ; Reynaud Juan[1,2] ; Fortune Brad[2] ; l J A[6] ; Sharpe Glen[7] ; Nicolela Marcelo[7] ; Chauhan Balwantray C[7] ; Yang Hongli[1,2] ;
机构： [1]Devers Eye Institute Optic Nerve Head Research Laboratory, Legacy Research Institute, Portland, OR, United States. [2]Devers Eye Institute Discoveries in Sight Research Laboratories, Legacy Research Institute, Portland, OR, United States. [3]Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Beijing, China. [4]Department of Ophthalmology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea. [5]Yebon Eye Clinic, Seoul, Korea. [6]Ophthalmic Engineering & Innovation Laboratory, Department of Biomedical Engineering, National University of Singapore, Singapore. [7]Department of Ophthalmology and Visual Sciences, Dalhousie University, Halifax, NS, Canada.
出处：
DOI： 10.1016/j.ajo.2023.03.002
ISSN：

摘要：
To use optical coherence tomography (OCT) to characterize optic nerve head (ONH) perineural canal (pNC) scleral bowing (pNC-SB) and pNC choroidal thickness (pNC-CT) in 69 highly myopic and 138 healthy, age-matched, control eyes.Cross-sectional, case control study.Within ONH radial B-scans, Bruch's membrane (BM), BM opening (BMO), the anterior scleral canal opening (ASCO) and the pNC scleral surface were segmented. BMO and ASCO planes and centroids were determined. pNC-SB was characterized within 30°Foveal-BMO (FoBMO) sectors by two parameters: pNC-SB-scleral slope (pNC-SB-SS) measured within three pNC segments (0-300, 300-700 and 700-1000 μm from the ASCO centroid); and pNC-SB-ASCO depth relative to a pNC scleral reference plane (pNC-SB-ASCOD). pNC-CT was calculated as the minimum distance between the scleral surface and BM at three pNC locations (300, 700, 1100 μm from the ASCO).pNC-SB increased and pNC-CT decreased with axial length (p < 0.0133; p < 0.0001) and age (p < 0.0211; p < 0.0004) among all study eyes. pNC-SB was increased (p < 0.001) and pNC-CT was decreased (p < 0.0279) in the highly myopic compared to control eyes and these differences were greatest in the inferior quadrant sectors (p < 0.0002). Sectoral pNC-SB was not related to sectoral pNC-CT in control eyes, but was inversely related to sectoral pNC-CT (p < 0.0001) in the highly myopic eyes.Our data suggest that pNC-SB is increased and pNC-CT is decreased in highly myopic eyes and that these phenomena are greatest in the inferior sectors. They support the hypothesis that sectors of maximum pNC-SB may predict sectors of greatest susceptibility to aging and glaucoma in future longitudinal studies of highly myopic eyes.Copyright © 2023. Published by Elsevier Inc.

基金：
Supported by a National Eye Institute Grant (NIH/NEI R01-EY021281), a grant from the Canadian National Institute for the Blind – Canadian Glaucoma Clinical Research Council; with additional unrestricted research support from a Mathers Fellowship award; Legacy Good Samaritan Foundation; the Alcon Research Institute, the Sears Medical Trust and Heidelberg Engineering, GmbH, Heidelberg, Germany.
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外文
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中科院(CAS)分区：
出版当年[2022]版：
大类 | 1 区 医学
小类 | 1 区 眼科学
最新[2023]版：
大类 | 1 区 医学
小类 | 1 区 眼科学
JCR分区：
出版当年[2021]版：
Q1 OPHTHALMOLOGY
最新[2023]版：
Q1 OPHTHALMOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2021版] 出版当年五年平均 出版前一年[2020版] 出版后一年[2022版]

第一作者：
第一作者机构： [1]Devers Eye Institute Optic Nerve Head Research Laboratory, Legacy Research Institute, Portland, OR, United States. [2]Devers Eye Institute Discoveries in Sight Research Laboratories, Legacy Research Institute, Portland, OR, United States. [*1]Optic Nerve Head Research Laboratory, Devers Eye Institute Legacy Research Institute 1225 NE 2nd Ave Portland
通讯作者：
通讯机构： [1]Devers Eye Institute Optic Nerve Head Research Laboratory, Legacy Research Institute, Portland, OR, United States. [2]Devers Eye Institute Discoveries in Sight Research Laboratories, Legacy Research Institute, Portland, OR, United States. [*1]Optic Nerve Head Research Laboratory, Devers Eye Institute Legacy Research Institute 1225 NE 2nd Ave Portland
推荐引用方式(GB/T 7714)：
Burgoyne Claude F,Wang Ya Xing,Jeoung Jin Wook,et al.OCT Optic Nerve Head Morphology in Myopia II: Peri-Neural Canal Scleral Bowing and Choroidal Thickness in High Myopia An American Ophthalmological Society Thesis[J].AMERICAN JOURNAL OF OPHTHALMOLOGY.2023,252:225-252.doi:10.1016/j.ajo.2023.03.002.
APA：
Burgoyne Claude F,Wang Ya Xing,Jeoung Jin Wook,Hong Seungwoo,Gardiner Stuart...&Yang Hongli.(2023).OCT Optic Nerve Head Morphology in Myopia II: Peri-Neural Canal Scleral Bowing and Choroidal Thickness in High Myopia An American Ophthalmological Society Thesis.AMERICAN JOURNAL OF OPHTHALMOLOGY,252,
MLA：
Burgoyne Claude F,et al."OCT Optic Nerve Head Morphology in Myopia II: Peri-Neural Canal Scleral Bowing and Choroidal Thickness in High Myopia An American Ophthalmological Society Thesis".AMERICAN JOURNAL OF OPHTHALMOLOGY 252.(2023):225-252

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