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TRIB2 safeguards naive T cell homeostasis during aging

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收录情况： ◇ SCIE

作者：
Cao Wenqiang[1,2,3,4] * ; Sturmlechner Ines[4] * ; Zhang Huimin[2,3,4] ; Jin Jun[2,4] ; Hu Bin[2,3] ; Jadhav Rohit R[2,3,4] ; Fang Fengqin[2,3,5] ; Weyand Cornelia M[2,3,4,6] ; Jo¨ rg J. Goronzy[2,3,4,6,7] ;
机构： [1]Key Laboratory of Major Chronic Diseases of Nervous System of Liaoning Province, Health Sciences Institute of China Medical University, Shenyang 110122, China [2]Department of Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, CA 94305, USA [3]Department of Medicine, Palo Alto Veterans Administration Healthcare System, Palo Alto, CA 94305, USA [4]Department of Immunology, Mayo Clinic College of Medicine and Science, Rochester, MN 55905, USA [5]Department of Laboratory Medicine, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200336, China [6]Department of Medicine, Division of Rheumatology, Mayo Clinic College of Medicine and Science, Rochester, MN 55905, USA [7]Robert and Arlene Kogod Center on Aging, Mayo Clinic College of Medicine and Science, Rochester, MN 55905, USA
出处：
DOI： 10.1016/j.celrep.2023.112195
ISSN：

摘要：
Naive CD4+ T cells are more resistant to age-related loss than naive CD8+ T cells, suggesting mechanisms that preferentially protect naive CD4+ T cells during aging. Here, we show that TRIB2 is more abundant in naive CD4+ than CD8+ T cells and counteracts quiescence exit by suppressing AKT activation. TRIB2 deficiency increases AKT activity and accelerates proliferation and differentiation in response to interleukin-7 (IL-7) in humans and during lymphopenia in mice. TRIB2 transcription is controlled by the lineage-determining transcription factors ThPOK and RUNX3. Ablation of Zbtb7b (encoding ThPOK) and Cbfb (obligatory RUNT cofactor) attenuates the difference in lymphopenia-induced proliferation between naive CD4+ and CD8+ cells. In older adults, ThPOK and TRIB2 expression wanes in naive CD4+ T cells, causing loss of naivety. These findings assign TRIB2 a key role in regulating T cell homeostasis and provide a model to explain the lesser resilience of CD8+ T cells to undergo changes with age.Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.

基金：
This work was supported by National Institutes of Health (NIH) R01AR042527, R01HL117913, R01AI108906, and R01HL142068 (all to C.M.W.); NIH R01AI108891, R01AG045779, R01AI129191, and U19AI057266 (all to J.J.G.); NIH T32AG049672 (to I.S.); and the National Natural Science Foundation of China 32270938 (to W.C.).
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外文
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中科院(CAS)分区：
出版当年[2022]版：
大类 | 1 区 生物学
小类 | 2 区 细胞生物学
最新[2023]版：
大类 | 1 区 生物学
小类 | 2 区 细胞生物学
JCR分区：
出版当年[2021]版：
Q1 CELL BIOLOGY
最新[2023]版：
Q1 CELL BIOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2021版] 出版当年五年平均 出版前一年[2020版] 出版后一年[2022版]

第一作者：
第一作者机构： [1]Key Laboratory of Major Chronic Diseases of Nervous System of Liaoning Province, Health Sciences Institute of China Medical University, Shenyang 110122, China [2]Department of Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, CA 94305, USA [3]Department of Medicine, Palo Alto Veterans Administration Healthcare System, Palo Alto, CA 94305, USA [4]Department of Immunology, Mayo Clinic College of Medicine and Science, Rochester, MN 55905, USA
共同第一作者：
通讯作者：
通讯机构： [1]Key Laboratory of Major Chronic Diseases of Nervous System of Liaoning Province, Health Sciences Institute of China Medical University, Shenyang 110122, China [2]Department of Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, CA 94305, USA [3]Department of Medicine, Palo Alto Veterans Administration Healthcare System, Palo Alto, CA 94305, USA [4]Department of Immunology, Mayo Clinic College of Medicine and Science, Rochester, MN 55905, USA [6]Department of Medicine, Division of Rheumatology, Mayo Clinic College of Medicine and Science, Rochester, MN 55905, USA [7]Robert and Arlene Kogod Center on Aging, Mayo Clinic College of Medicine and Science, Rochester, MN 55905, USA
推荐引用方式(GB/T 7714)：
Cao Wenqiang,Sturmlechner Ines,Zhang Huimin,et al.TRIB2 safeguards naive T cell homeostasis during aging[J].CELL REPORTS.2023,42(3):doi:10.1016/j.celrep.2023.112195.
APA：
Cao Wenqiang,Sturmlechner Ines,Zhang Huimin,Jin Jun,Hu Bin...&Jo¨ rg J. Goronzy.(2023).TRIB2 safeguards naive T cell homeostasis during aging.CELL REPORTS,42,(3)
MLA：
Cao Wenqiang,et al."TRIB2 safeguards naive T cell homeostasis during aging".CELL REPORTS 42..3(2023)

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