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CHST2-mediated sulfation of MECA79 antigens is critical for breast cancer cell migration and metastasis

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收录情况： ◇ SCIE

作者：
Zhang Dan[1,2,3] * ; Zhang Yihong[1,3] * ; Zou Xiuqun[1,3] ; Li Mengying[1,3] ; Zhang Hui[1,3] ; Du Yaning[1,3] ; Wang Jiamin[1,3] ; Peng Chicheng[4] ; Dong Chunyan[2] ; Hou Zhaoyuan[1,3] ;
机构： [1]Hongqiao Institute of Medicine, Tongren Hospital/Faculty of Basic Medicine, Shanghai Jiaotong University School of Medicine, Shanghai, China [2]Breast Cancer Center, ShanghaiEast Hospital, School of Medicine, Tongji University, Shanghai, China [3]Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Department of Biochemistry &Molecular Cellular Biology, Shanghai Jiaotong University School of Medicine, Shanghai, China [4]Shandong NARUI Biotechnology Co., LTD, Shandong, China
出处：
DOI： 10.1038/s41419-023-05797-x
ISSN：

摘要：
Snail is a denoted transcriptional repressor that plays key roles in epithelial-mesenchymal transition (EMT) and metastasis. Lately, a plethora of genes can be induced by stable expression of Snail in multiple cell lines. However, the biological roles of these upregulated genes are largely elusive. Here, we report identification of a gene encoding the key GlcNAc sulfation enzyme CHST2 is induced by Snail in multiple breast cancer cells. Biologically, CHST2 depletion results in inhibition of breast cancer cell migration and metastasis, while overexpression of CHST2 promotes cell migration and lung metastasis in nude mice. In addition, the expression level of MECA79 antigen is elevated and blocking the cell surface MECA79 antigen with specific antibodies can override cell migration mediated by CHST2 upregulation. Moreover, the sulfation inhibitor sodium chlorate effectively inhibits the cell migration induced by CHST2. Collectively, these data provide novel insights into the biology of Snail/CHST2/MECA79 axis in breast cancer progression and metastasis as well as potential therapeutic strategy for the diagnosis and treatment of breast cancer metastasis.© 2023. The Author(s).

基金：
Shandong Provincial Natural Science Foundation (ZR2021ZD16); the National Natural Science Foundation of China (82273392, 81903003); Shanghai Frontiers Science Center of Cellular Homeostasis and Human Diseases.
语种：
外文
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出版当年[2022]版：
大类 | 1 区 生物学
小类 | 2 区 细胞生物学
最新[2023]版：
大类 | 1 区 生物学
小类 | 2 区 细胞生物学
JCR分区：
出版当年[2021]版：
Q1 CELL BIOLOGY
最新[2023]版：
Q1 CELL BIOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2021版] 出版当年五年平均 出版前一年[2020版] 出版后一年[2022版]

第一作者：
第一作者机构： [1]Hongqiao Institute of Medicine, Tongren Hospital/Faculty of Basic Medicine, Shanghai Jiaotong University School of Medicine, Shanghai, China [2]Breast Cancer Center, ShanghaiEast Hospital, School of Medicine, Tongji University, Shanghai, China [3]Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Department of Biochemistry &Molecular Cellular Biology, Shanghai Jiaotong University School of Medicine, Shanghai, China
共同第一作者：
通讯作者：
通讯机构： [1]Hongqiao Institute of Medicine, Tongren Hospital/Faculty of Basic Medicine, Shanghai Jiaotong University School of Medicine, Shanghai, China [3]Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Department of Biochemistry &Molecular Cellular Biology, Shanghai Jiaotong University School of Medicine, Shanghai, China
推荐引用方式(GB/T 7714)：
Zhang Dan,Zhang Yihong,Zou Xiuqun,et al.CHST2-mediated sulfation of MECA79 antigens is critical for breast cancer cell migration and metastasis[J].CELL DEATH & DISEASE.2023,14(4):doi:10.1038/s41419-023-05797-x.
APA：
Zhang Dan,Zhang Yihong,Zou Xiuqun,Li Mengying,Zhang Hui...&Hou Zhaoyuan.(2023).CHST2-mediated sulfation of MECA79 antigens is critical for breast cancer cell migration and metastasis.CELL DEATH & DISEASE,14,(4)
MLA：
Zhang Dan,et al."CHST2-mediated sulfation of MECA79 antigens is critical for breast cancer cell migration and metastasis".CELL DEATH & DISEASE 14..4(2023)

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