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Expression of OLR1 gene on tumor-associated macrophages of head and neck squamous cell carcinoma, and its correlation with clinical outcome

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机构： [1]Beijing Key Laboratory for Genetics of Birth Defects, Beijing Pediatric Research Institute [2]MOE Key Laboratory of Major Diseases in Children [3]Rare Disease Center, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, China [4]Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, China [5]Department of Otolaryngology-Head and Neck Surgery, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Peking Union Medical College Chinese Academy of Medical Sciences, Beijing, China [6]Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai, China [7]Division of Immunotherapy, Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD, USA

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Head and neck squamous cell carcinoma (HNSCC) is one of the most heavily immune infiltrated human tumors, having distinct immune subtypes associated with different molecular characteristics and clinical outcomes. The tumor microenvironment (TME) of HNSCC which was dominated by tumor-associated macrophages (TAMs) had a relatively inferior prognosis. High levels of oxidized low-density lipoprotein receptor 1 (OLR1) expression are associated with more aggressive and metastatic characteristics in multiple cancers. However, the link between the OLR1 expression and immunosuppression of TME, and the molecular mechanisms which govern intratumoral TAMs behavior are unclear. Here, we performed the transcriptional analysis based on a single-cell RNA-sequencing (scRNA-seq) dataset of HNSCC, and found that the OLR1 expression was specifically enriched on the TAMs. Evaluation of protein expression within histologic sections of primary HNSCC patient samples showed a co-expression pattern of OLR1 and CD68 on macrophages. A total of 498 tumor samples of HNSCC patients from The Cancer Genome Atlas (TCGA) database were also analyzed. Remarkably, OLR1 expression was dramatically higher in HNSCC tissues than that in adjacent normal tissues, and the patients with high levels of OLR1 expression had significantly unfavorable overall survival (Hazard Ratio = 1.724, log-rank P-value = 0.0066) when compared to patients harboring low expression levels of OLR1. In summary, we reported that the specific expression of OLR1 on the TAMs was significantly correlated with poor survival outcomes, revealing that OLR1 could serve as a potential prognosis marker and promising target for immunotherapy in HNSCC.© 2023 The Author(s). Published with license by Taylor & Francis Group, LLC.

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出版当年[2022]版：

大类 | 2 区医学

小类 | 2 区免疫学 3 区肿瘤学

最新[2023]版：

大类 | 2 区医学

小类 | 2 区免疫学 2 区肿瘤学

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出版当年[2021]版：

Q1 IMMUNOLOGY Q1 ONCOLOGY

最新[2023]版：

Q1 IMMUNOLOGY Q1 ONCOLOGY

影响因子： 6.5 最新[2023版] 7.2 最新五年平均 7.723 出版当年[2021版] 8.24 出版当年五年平均 8.11 出版前一年[2020版] 7.2 出版后一年[2022版]

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第一作者机构： [1]Beijing Key Laboratory for Genetics of Birth Defects, Beijing Pediatric Research Institute [2]MOE Key Laboratory of Major Diseases in Children [3]Rare Disease Center, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, China [*1]Beijing Key Laboratory for Genetics of Birth Defects, Beijing Pediatric Research Institute [*2]MOE Key Laboratory of Major Diseases in Children [*3]Rare Disease Center, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing 100045, China

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通讯作者：

通讯机构： [1]Beijing Key Laboratory for Genetics of Birth Defects, Beijing Pediatric Research Institute [2]MOE Key Laboratory of Major Diseases in Children [3]Rare Disease Center, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, China [5]Department of Otolaryngology-Head and Neck Surgery, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Peking Union Medical College Chinese Academy of Medical Sciences, Beijing, China [*1]Beijing Key Laboratory for Genetics of Birth Defects, Beijing Pediatric Research Institute [*2]MOE Key Laboratory of Major Diseases in Children [*3]Rare Disease Center, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing 100045, China [*4]Department of Otolaryngology-Head and Neck Surgery, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100005, China

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