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The prognostic value of controlling nutritional status (CONUT) score-based nomogram on extranodal natural killer/T cell lymphoma patients

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机构: [1]Department of Hematology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221006, Jiangsu, China. [2]Department of Hematology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China. [3]Department of Hematology, The Affiliated Hospital of Jining Medical University, Jining, 272000, Shandong, China. [4]Department of Hematology, Qilu Hospital of Shandong University, Jinan, 250012, Shandong, China. [5]Department of Hematology, Tai'an Central Hospital, Tai'an, 271000, Shandong, China. [6]Department of Hematology, The First People's Hospital of Lianyungang, Lianyungang, 222061, Jiangsu, China. [7]Department of Hematology, The General Hospital of Wanbei Coal-Electric Group, Suzhou, 234011, Anhui, China. [8]Department of Hematology, Yancheng First People's Hospital, Yancheng, 224001, Jiangsu, China. [9]Department of Hematology, The First People's Hospital of Huai'an, Huai'an, 223300, Jiangsu, China. [10]Department of Hematology, Beijing Tongren Hospital, Capital Medical University, Beijing, 100005, China. [11]Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, 230032, Anhui, China.
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关键词: Controlling Nutritional Status score  Extranodal natural killer/T cell lymphoma  Nomogram  Nutritional indices  Prognosis

摘要:
Controlling nutritional status (CONUT) score as an original nutritional assessment tool can be used to assess the prognosis of patients with a variety of malignancies. However, the predictive power of CONUT in extranodal natural killer/T cell lymphoma (ENKTL) patients has never been demonstrated. Our retrospective multicenter study aimed to explore the prognostic value of CONUT in newly diagnosed ENKTL. A total of 1085 newly diagnosed ENKTL patients between 2003 and 2021 were retrospectively retrieved. Cox proportional hazard model was used to explore the prognostic factors of overall survival (OS). The survival rate of ENKTL was evaluated using Kaplan-Meier analysis, and log-rank test was applied to the difference between groups. We investigated the prognostic performance of CONUT, the International Prognostic Index (IPI), the Korean Prognostic Index (KPI), and the Prognostic Index of Natural Killer Cell Lymphoma (PINK) using the receiver operating characteristic (ROC) curve and decision curve analysis (DCA). The median age at diagnosis for the whole cohort was 47 years, and the male to female ratio was 2.2:1. The 5-year OS for all patients was 72.2%. Multivariable analysis showed that CONUT, age, bone marrow involvement, ECOG PS score, and Chinese Southwest Oncology Group and Asia Lymphoma Study Group ENKTL stage were identified as independent predictive factors for OS. Based on multivariable results, a prognostic nomogram was developed. Subgroup analysis demonstrated that patients with severe malnutrition had poorest clinical outcome. In addition, ROC curves and DCA analysis proved that compared with IPI, KPI, and PINK models, the CONUT score-based nomogram showed a better prognostic predictive efficiency of ENKTL. CONUT could effectively stratify the prognosis of ENKTL and the proposed nomogram based on CONUT was an effective prognostic model for prediction.© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

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出版当年[2022]版:
大类 | 3 区 医学
小类 | 3 区 血液学
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大类 | 3 区 医学
小类 | 3 区 血液学
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Q2 HEMATOLOGY
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Q2 HEMATOLOGY

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第一作者机构: [1]Department of Hematology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221006, Jiangsu, China.
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