The aim of this study was to introduce an optimized version of the Corvis Biomechanical Index for Chinese population (cCBI).Retrospective, multicenter clinical validity-enhancement study.Patients were included from seven clinics (Beijing, Shenyang, Guangzhou, Shanghai, Wenzhou, Chongqing and Tianjin). Logistic regression was employed to optimize the values of the constants of the CBI, based on Database 1 as the development dataset (six out of 7 clinics), to create a new version of the index named cCBI. The factors of the CBI (A1Velocity, ARTh, Stiffness Parameter-A, DARatio2mm and Inverse Integrated Radius) and the cut-off value were kept the same (0.5). With the formation of cCBI determined, it was validated on Database 2 (1 out 7 of the clinics).Two thousand four hundred and seventy-three patients (healthy and keratoconus) were included. In the database 2, the Area Under the Curve (AUC) of the cCBI was 0.985 with a 93.4 % specificity and 95.5 % sensitivity. In the same Dataset the original CBI produced an AUC of 0.978 with a 68.1 % specificity and 97.7 % sensitivity. There was a statistically significant difference between the ROC curve of cCBI and CBI (De Long p=0.0009) CONCLUSION: :The new cCBI for Chinese patients was shown to be statistically significantly better when compared to CBI to separate healthy from keratoconic eyes. The presence of an external validation dataset confirms this finding and suggests the use of cCBI in everyday clinical practice to aid in the diagnosis of keratoconus in Chinese ethnicity.Copyright © 2023. Published by Elsevier Inc.