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The global epidemiology and clinical diagnosis of Acanthamoeba keratitis

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机构: [1]Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing 100005, China
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关键词: Acanthamoeba keratitis Epidemiology Diagnosis Genotype

摘要:
Acanthamoeba keratitis is a rare parasitic infection of the cornea that can lead to permanent blindness if not diagnosed and treated promptly. We collected data on the incidences of Acanthamoeba keratitis from 20 countries and calculated an annual incidence of 23,561 cases, with the lowest rates in Tunisia and Belgium, and the highest in India. We analyzed 3755 Acanthamoeba sequences from the GenBank database across Asia, Europe, North America, South America, and Oceania and genotyped them into T1, T2, T3, T4, T5, T10, T11, T12, and T15. Many genotypes possess different characteristics, yet T4 is the most prevalent genotype. As efficient treatment against Acanthamoeba remains lacking, prevention from early diagnosis via staining, PCR, or in vivo confocal microscopy (IVCM) becomes significant for the condition's prognosis. IVCM is the most recommended approach for the early detection of Acanthamoeba. If IVCM is unavailable, PCR should be used as an alternative.Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.

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出版当年[2022]版:
大类 | 3 区 医学
小类 | 3 区 传染病学 3 区 公共卫生、环境卫生与职业卫生
最新[2023]版:
大类 | 3 区 医学
小类 | 3 区 传染病学 3 区 公共卫生、环境卫生与职业卫生
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出版当年[2021]版:
Q1 INFECTIOUS DISEASES Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
最新[2023]版:
Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Q1 INFECTIOUS DISEASES

影响因子: 最新[2023版] 最新五年平均 出版当年[2021版] 出版当年五年平均 出版前一年[2020版] 出版后一年[2022版]

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第一作者机构: [1]Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing 100005, China
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