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Adduction induces large optic nerve head deformations in subjects with normal-tension glaucoma

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机构： [1]Ophthalmic Engineering & Innovation Laboratory (OEIL), Singapore Eye Research Institute, Singapore National Eye Center, Singapore [2]Department of Biomedical Engineering, National University of Singapore, Singapore [3]Singapore Eye Research Institute, Singapore National Eye Centre, Singapore [4]Beijing Advanced Innovation Center for Biomedical Engineering, Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, Beijing, China [5]NIHR (National Institute of Health Research) Biomedical Sciences Centre, Moorfields Eye Hospital and UCL Institute of Ophthalmology, London, United Kingdom [6]Duke-NUS Medical School, Singapore [7]Yong Loo Lin School of Medicine, National University of Singapore [8]Institute for Molecular and Clinical Ophthalmology, Basel, Switzerland

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To assess intraocular pressure (IOP)-induced and gaze-induced optic nerve head (ONH) strains in subjects with high-tension glaucoma (HTG) and normal-tension glaucoma (NTG).Clinic-based cross-sectional study.The ONH from one eye of 228 subjects (114 subjects with HTG (pre-treatment IOP≥21 mm Hg) and 114 with NTG (pre-treatment IOP<21 mm Hg)) was imaged with optical coherence tomography (OCT) under the following conditions: (1) OCT primary gaze, (2) 20° adduction from OCT primary gaze, (3) 20° abduction from OCT primary gaze and (4) OCT primary gaze with acute IOP elevation (to approximately 33 mm Hg). We then performed digital volume correlation analysis to quantify IOP-induced and gaze-induced ONH tissue deformations and strains.Across all subjects, adduction generated high effective strain (4.4%±2.3%) in the LC tissue with no significant difference (p>0.05) with those induced by IOP elevation (4.5%±2.4%); while abduction generated significantly lower (p=0.01) effective strain (3.1%±1.9%). The lamina cribrosa (LC) of HTG subjects exhibited significantly higher effective strain than those of NTG subjects under IOP elevation (HTG: 4.6%±1.7% vs NTG: 4.1%±1.5%, p<0.05). Conversely, the LC of NTG subjects exhibited significantly higher effective strain than those of HTG subjects under adduction (NTG: 4.9%±1.9% vs HTG: 4.0%±1.4%, p<0.05).We found that NTG subjects experienced higher strains due to adduction than HTG subjects, while HTG subjects experienced higher strain due to IOP elevation than NTG subjects-and that these differences were most pronounced in the LC tissue.© Author(s) (or their employer(s)) 2023. No commercial re-use. See rights and permissions. Published by BMJ.

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出版当年[2022]版：

大类 | 2 区

医学

小类 | 1 区眼科学

最新[2023]版：

大类 | 2 区

医学

小类 | 2 区眼科学

第一作者：

第一作者机构： [1]Ophthalmic Engineering & Innovation Laboratory (OEIL), Singapore Eye Research Institute, Singapore National Eye Center, Singapore [2]Department of Biomedical Engineering, National University of Singapore, Singapore

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通讯机构： [1]Ophthalmic Engineering & Innovation Laboratory (OEIL), Singapore Eye Research Institute, Singapore National Eye Center, Singapore [6]Duke-NUS Medical School, Singapore [8]Institute for Molecular and Clinical Ophthalmology, Basel, Switzerland [*1]Ophthalmic Engineering & Innovation Laboratory (OEIL), Singapore Eye Research Institute (SERI), The Academia, 20 College Road, Discovery Tower Level 6, Singapore.

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