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Factors associated with severe corneal endothelial damage following acute primary angle closure in Chinese subjects

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收录情况： ◇ SCIE

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机构： [1]Beijing Tongren Eye Center, Beijing Tongren Hospital, Beijing Ophthalmology & Visual Science Key Lab, Capital Medical University, No. 1 Dongjiao Min Xiang, Dongcheng District, Beijing, 100730, China. [2]Shenzhen Eye Hospital, Jinan University, Shenzhen Eye Institute, Shenzhen, China. [3]Hebei Eye Hospital, Xingtai, Hebei, China. [4]Beijing Institute of Ophthalmology, Capital Medical University, Beijing, China

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关键词： Acute angle closure Corneal endothelium Corneal damage Endothelial cell density

摘要：

To investigate the corneal endothelial damage caused by acute primary angle closure (APAC) and related risk factors for severe corneal endothelial cell damage in Chinese subjects.In this multicentre retrospective study, 160 Chinese patients (171 eyes) diagnosed with APAC were recruited. Endothelial cell density (ECD) and morphological changes short after APAC were studied. Univariate regression and multivariate regression were used to identify risk factors associated with the extent of ECD reduction, including age, gender, education level, patients' location, systemic diseases, APAC duration (hours), highest recorded intraocular pressure (IOP), and presenting IOP. Factors associated with the probability of severe corneal damage (ECD lower than 1000/mm2) were analysed based on a linear function.After one APAC episode, 12.28% eyes had ECD lower than 1000/mm2, 30.41% had ECD between 1000 and 2000/mm2, and 57.31% had ECD more than 2000/mm2. Attack duration was the only factor associated with severe endothelial damage (p < 0.0001). If the attack were to be subsided within 15.0 h, possibility of ECD lower than 1000/mm2 could be controlled under 1%.Shortly after the abortion of APAC, 12.28% patients experienced severe endothelial cell damage with ECD less than 1000/mm2. The only factor associated with severe ECD decrease was attack duration. Immediate and effective treatment is pivotal for preserving corneal endothelial function in APAC patients.© 2023. The Author(s).

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出版当年[2022]版：

大类 | 3 区医学

小类 | 3 区眼科学

最新[2023]版：

大类 | 3 区医学

小类 | 3 区眼科学

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出版当年[2021]版：

Q2 OPHTHALMOLOGY

最新[2023]版：

Q2 OPHTHALMOLOGY

影响因子： 2.4 最新[2023版] 2.7 最新五年平均 3.535 出版当年[2021版] 3.394 出版当年五年平均 3.117 出版前一年[2020版] 2.7 出版后一年[2022版]

第一作者：

第一作者机构： [1]Beijing Tongren Eye Center, Beijing Tongren Hospital, Beijing Ophthalmology & Visual Science Key Lab, Capital Medical University, No. 1 Dongjiao Min Xiang, Dongcheng District, Beijing, 100730, China.

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